ENSMUSG00000000028


Mus musculus

Features
Gene ID: ENSMUSG00000000028
  
Biological name :Cdc45
  
Synonyms : Cdc45 / Cell division control / Q9Z1X9
  
Possible biological names infered from orthology : cell division cycle 45 / O75419
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A3
Gene start: 18780447
Gene end: 18811987
  
Corresponding Affymetrix probe sets: 10438378 (MoGene1.0st)   1416575_at (Mouse Genome 430 2.0 Array)   1457838_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000028
Ensembl peptide - ENSMUSP00000094753
Ensembl peptide - ENSMUSP00000111248
NCBI entrez gene - 12544     See in Manteia.
MGI - MGI:1338073
RefSeq - XM_011245813
RefSeq - NM_001161623
RefSeq - NM_009862
RefSeq - XM_006521744
RefSeq Peptide - NP_001155095
RefSeq Peptide - NP_001345135
RefSeq Peptide - NP_033992
swissprot - Q3UI99
swissprot - F8WJ72
swissprot - Q9Z1X9
swissprot - D3Z0L5
Ensembl - ENSMUSG00000000028
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc45ENSDARG00000043720Danio rerio
 CDC45ENSGALG00000001616Gallus gallus
 CDC45ENSG00000093009Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003874  CDC45 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000727 double-strand break repair via break-induced replication IBA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0031938 regulation of chromatin silencing at telomere IBA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IBA
 biological_processGO:1902977 mitotic DNA replication preinitiation complex assembly IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005656 nuclear pre-replicative complex IBA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0031261 DNA replication preinitiation complex IBA
 cellular_componentGO:0031298 replication fork protection complex IBA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003688 DNA replication origin binding IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0043138 3"-5" DNA helicase activity IBA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt3tm1Amc/Wnt3tm2Amc,Tg(Rarb-cre)1Mrc/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

 MP:0012114 absent inner cell mass proliferation 
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042489 Clspn / Q80YR7 / Claspin / Q9HAW4*  / reaction / complex
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000002297 A / Dbf4 / Q9QZ41 / Q9UBU7* / DBF4 zinc finger*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000026669 Mcm10 / Q0VBD2 / minichromosome maintenance 10 replication initiation factor / Q7L590*  / reaction / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / reaction / complex
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction
 ENSMUSG00000029283 Cdc7 / Q9Z0H0 / Cell division cycle 7-related protein kinase / O00311* / cell division cycle 7*  / complex / reaction
 ENSMUSG00000017499 Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction






 

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