ENSMUSG00000029283


Mus musculus

Features
Gene ID: ENSMUSG00000029283
  
Biological name :Cdc7
  
Synonyms : Cdc7 / Cell division cycle 7-related protein kinase / Q9Z0H0
  
Possible biological names infered from orthology : cell division cycle 7 / O00311
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E5
Gene start: 106964322
Gene end: 106984432
  
Corresponding Affymetrix probe sets: 10523802 (MoGene1.0st)   1426002_a_at (Mouse Genome 430 2.0 Array)   1426021_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112392
Ensembl peptide - ENSMUSP00000031221
Ensembl peptide - ENSMUSP00000075792
Ensembl peptide - ENSMUSP00000113385
Ensembl peptide - ENSMUSP00000119612
NCBI entrez gene - 12545     See in Manteia.
MGI - MGI:1309511
RefSeq - XM_017320634
RefSeq - NM_001271566
RefSeq - NM_001271567
RefSeq - NM_001271568
RefSeq - NM_009863
RefSeq - XM_006534737
RefSeq Peptide - NP_001258497
RefSeq Peptide - NP_033993
RefSeq Peptide - NP_001258495
RefSeq Peptide - NP_001258496
swissprot - Q66JY4
swissprot - Q9Z0H0
swissprot - G3UVV7
Ensembl - ENSMUSG00000029283
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc7ENSDARG00000023584Danio rerio
 CDC7ENSGALG00000006051Gallus gallus
 CDC7ENSG00000097046Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000727 double-strand break repair via break-induced replication IBA
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0010571 positive regulation of nuclear cell cycle DNA replication IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0044770 cell cycle phase transition IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0045171 intercellular bridge IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Cdc7tm1Hmas/Cdc7tm1Hmas,Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000002297 A / Dbf4 / Q9QZ41 / Q9UBU7* / DBF4 zinc finger*  / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000026669 Mcm10 / Q0VBD2 / minichromosome maintenance 10 replication initiation factor / Q7L590*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction
 ENSMUSG00000042489 Clspn / Q80YR7 / Claspin / Q9HAW4*  / complex / reaction
 ENSMUSG00000000028 Cdc45 / Q9Z1X9 / Cell division control / O75419* / cell division cycle 45*  / reaction / complex
 ENSMUSG00000017499 Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction






 

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