Manteia

ENSMUSG00000002297

Mus musculus

Features

Gene ID:	ENSMUSG00000002297

Biological name :	Dbf4

Synonyms :	A / Dbf4 / Q9QZ41

Possible biological names infered from orthology :	DBF4 zinc finger / Q9UBU7

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	A1
Gene start:	8396973
Gene end:	8422716

Corresponding Affymetrix probe sets:	10528077 (MoGene1.0st) 1418334_at (Mouse Genome 430 2.0 Array) 1430545_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000132985 Ensembl peptide - ENSMUSP00000002368 Ensembl peptide - ENSMUSP00000129317 Ensembl peptide - ENSMUSP00000132906 NCBI entrez gene - 27214 See in Manteia. MGI - MGI:1351328 RefSeq - XM_011240670 RefSeq - NM_001190717 RefSeq - NM_013726 RefSeq Peptide - NP_001177646 RefSeq Peptide - NP_038754 swissprot - Q9QZ41 swissprot - B2RS44 swissprot - F7AV51 swissprot - E9PW04 Ensembl - ENSMUSG00000002297

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006260	DNA replication	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007089	traversing start control point of mitotic cell cycle	ISA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0016604	nuclear body	IEA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	ISA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Activation of ATR in response to replication stress

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Coq6^{tm1b(EUCOMM)Hmgu}/Coq6⁺ Genetic Background: C57BL/6N-Coq6^{tm1b(EUCOMM)Hmgu}/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000751	Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*	/ reaction / complex
ENSMUSG00000029283	Cdc7 / Q9Z0H0 / Cell division cycle 7-related protein kinase / O00311* / cell division cycle 7*	/ complex
ENSMUSG00000000028	Cdc45 / Q9Z1X9 / Cell division control / O75419* / cell division cycle 45*	/ complex / reaction
ENSMUSG00000042489	Clspn / Q80YR7 / Claspin / Q9HAW4*	/ reaction / complex
ENSMUSG00000012483	Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*	/ reaction / complex
ENSMUSG00000026669	Mcm10 / Q0VBD2 / minichromosome maintenance 10 replication initiation factor / Q7L590*	/ complex / reaction
ENSMUSG00000025358	Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*	/ reaction / complex
ENSMUSG00000032409	Atr / ATR serine/threonine kinase / Q13535*	/ reaction
ENSMUSG00000017499	Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*	/ complex / reaction
ENSMUSG00000028884	Rpa2 / replication protein A2 / P15927*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr