ENSG00000006634


Homo sapiens

Features
Gene ID: ENSG00000006634
  
Biological name :DBF4
  
Synonyms : DBF4 / DBF4 zinc finger / Q9UBU7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q21.12
Gene start: 87876216
Gene end: 87909541
  
Corresponding Affymetrix probe sets: 204244_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000414083
Ensembl peptide - ENSP00000265728
Ensembl peptide - ENSP00000389397
Ensembl peptide - ENSP00000407116
NCBI entrez gene - 10926     See in Manteia.
OMIM - 604281
RefSeq - NM_001318060
RefSeq - NM_001318061
RefSeq - NM_001318062
RefSeq - NM_006716
RefSeq Peptide - NP_001304990
RefSeq Peptide - NP_001304989
RefSeq Peptide - NP_006707
RefSeq Peptide - NP_001304991
swissprot - Q9UBU7
swissprot - F8WF77
swissprot - B4DXK0
Ensembl - ENSG00000006634
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dbf4ENSDARG00000074796Danio rerio
 ENSGALG00000008963Gallus gallus
 A ENSMUSG00000002297Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DBF4B / Q8NFT6 / DBF4 zinc finger BENSG0000016169221


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR006572  Zinc finger, DBF-type
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000097046 CDC7 / O00311 / cell division cycle 7  / complex
 ENSG00000065328 MCM10 / Q7L590 / minichromosome maintenance 10 replication initiation factor  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000204086 RPA4 / Q13156 / replication protein A4  / complex / reaction
 ENSG00000092853 CLSPN / Q9HAW4 / claspin  / reaction / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction / complex
 ENSG00000094804 CDC6 / Q99741 / cell division cycle 6  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000093009 CDC45 / O75419 / cell division cycle 45  / complex / reaction
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction






 

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