ENSG00000097046


Homo sapiens

Features
Gene ID: ENSG00000097046
  
Biological name :CDC7
  
Synonyms : CDC7 / cell division cycle 7 / O00311
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p22.1
Gene start: 91500893
Gene end: 91525764
  
Corresponding Affymetrix probe sets: 204510_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398077
Ensembl peptide - ENSP00000234626
Ensembl peptide - ENSP00000393139
NCBI entrez gene - 8317     See in Manteia.
OMIM - 603311
RefSeq - XM_017002427
RefSeq - NM_001134419
RefSeq - NM_001134420
RefSeq - NM_003503
RefSeq - XM_005271241
RefSeq - XM_005271244
RefSeq - XM_017002425
RefSeq - XM_017002426
RefSeq Peptide - NP_001127891
RefSeq Peptide - NP_001127892
RefSeq Peptide - NP_003494
swissprot - B1AMW7
swissprot - O00311
Ensembl - ENSG00000097046
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc7ENSDARG00000023584Danio rerio
 CDC7ENSGALG00000006051Gallus gallus
 Cdc7ENSMUSG00000029283Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000727 double-strand break repair via break-induced replication IBA
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0010571 positive regulation of nuclear cell cycle DNA replication IMP
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0044770 cell cycle phase transition IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0045171 intercellular bridge IDA
 cellular_componentGO:0072686 mitotic spindle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000065328 MCM10 / Q7L590 / minichromosome maintenance 10 replication initiation factor  / complex / reaction
 ENSG00000094804 CDC6 / Q99741 / cell division cycle 6  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction / complex
 ENSG00000092853 CLSPN / Q9HAW4 / claspin  / complex / reaction
 ENSG00000204086 RPA4 / Q13156 / replication protein A4  / reaction / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000006634 DBF4 / Q9UBU7 / DBF4 zinc finger  / complex
 ENSG00000093009 CDC45 / O75419 / cell division cycle 45  / complex / reaction
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction






 

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