Manteia

ENSG00000117748

Homo sapiens

Features

Gene ID:	ENSG00000117748

Biological name :	RPA2

Synonyms :	P15927 / replication protein A2 / RPA2

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	1
Strand:	-1
Band:	p35.3
Gene start:	27891524
Gene end:	27914746

Corresponding Affymetrix probe sets:	201756_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000363017 Ensembl peptide - ENSP00000363015 Ensembl peptide - ENSP00000387649 Ensembl peptide - ENSP00000413541 Ensembl peptide - ENSP00000363021 NCBI entrez gene - 6118 See in Manteia. OMIM - 179836 RefSeq - NM_001355129 RefSeq - NM_001286076 RefSeq - NM_001297558 RefSeq - NM_002946 RefSeq Peptide - NP_001273005 RefSeq Peptide - NP_001284487 RefSeq Peptide - NP_001342058 RefSeq Peptide - NP_002937 swissprot - P15927 swissprot - Q5TEJ0 swissprot - Q5TEJ7 Ensembl - ENSG00000117748

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rpa2	ENSDARG00000037188	Danio rerio
RPA2	ENSGALG00000000734	Gallus gallus
Rpa2	ENSMUSG00000028884	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
RPA4 / Q13156 / replication protein A4	ENSG00000204086	41

Protein motifs (from Interpro)

Interpro ID	Name
IPR012340	Nucleic acid-binding, OB-fold
IPR014646	Replication factor A protein 2
IPR014892	Replication protein A, C-terminal
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036390	Winged helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000082	G1/S transition of mitotic cell cycle	TAS
biological_process	GO:0000723	telomere maintenance	IC
biological_process	GO:0000724	double-strand break repair via homologous recombination	IMP
biological_process	GO:0006260	DNA replication	TAS
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006283	transcription-coupled nucleotide-excision repair	TAS
biological_process	GO:0006284	base-excision repair	IDA
biological_process	GO:0006289	nucleotide-excision repair	IMP
biological_process	GO:0006293	nucleotide-excision repair, preincision complex stabilization	TAS
biological_process	GO:0006294	nucleotide-excision repair, preincision complex assembly	TAS
biological_process	GO:0006295	nucleotide-excision repair, DNA incision, 3"-to lesion	TAS
biological_process	GO:0006296	nucleotide-excision repair, DNA incision, 5"-to lesion	TAS
biological_process	GO:0006297	nucleotide-excision repair, DNA gap filling	TAS
biological_process	GO:0006298	mismatch repair	TAS
biological_process	GO:0006310	DNA recombination	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	IMP
biological_process	GO:0019985	translesion synthesis	TAS
biological_process	GO:0031571	mitotic G1 DNA damage checkpoint	IMP
biological_process	GO:0032201	telomere maintenance via semi-conservative replication	TAS
biological_process	GO:0033683	nucleotide-excision repair, DNA incision	TAS
biological_process	GO:0034502	protein localization to chromosome	IDA
biological_process	GO:0036297	interstrand cross-link repair	TAS
biological_process	GO:0042276	error-prone translesion synthesis	TAS
biological_process	GO:0042769	DNA damage response, detection of DNA damage	TAS
biological_process	GO:0070987	error-free translesion synthesis	TAS
biological_process	GO:1900034	regulation of cellular response to heat	TAS
biological_process	GO:1901796	regulation of signal transduction by p53 class mediator	TAS
biological_process	GO:2000001	regulation of DNA damage checkpoint	IMP
cellular_component	GO:0000781	chromosome, telomeric region	IDA
cellular_component	GO:0000784	nuclear chromosome, telomeric region	HDA
cellular_component	GO:0000785	chromatin	IDA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005654	nucleoplasm	IDA
cellular_component	GO:0005662	DNA replication factor A complex	IPI
cellular_component	GO:0016604	nuclear body	IDA
cellular_component	GO:0016605	PML body	IEA
cellular_component	GO:0035861	site of double-strand break	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003684	damaged DNA binding	IDA
molecular_function	GO:0003697	single-stranded DNA binding	ISS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0019899	enzyme binding	IPI
molecular_function	GO:0019903	protein phosphatase binding	IPI
molecular_function	GO:0031625	ubiquitin protein ligase binding	IPI
molecular_function	GO:0047485	protein N-terminus binding	IEA
molecular_function	GO:0098505	G-rich strand telomeric DNA binding	IDA

Pathways (from Reactome)

Pathway description

Translesion synthesis by REV1

Recognition of DNA damage by PCNA-containing replication complex

Translesion Synthesis by POLH

Removal of the Flap Intermediate from the C-strand

Activation of ATR in response to replication stress

Regulation of HSF1-mediated heat shock response

HSF1 activation

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

PCNA-Dependent Long Patch Base Excision Repair

Translesion synthesis by POLK

Translesion synthesis by POLI

Termination of translesion DNA synthesis

HDR through Single Strand Annealing (SSA)

HDR through Homologous Recombination (HRR)

Processing of DNA double-strand break ends

Presynaptic phase of homologous DNA pairing and strand exchange

Formation of Incision Complex in GG-NER

Gap-filling DNA repair synthesis and ligation in GG-NER

Dual Incision in GG-NER

Dual incision in TC-NER

Gap-filling DNA repair synthesis and ligation in TC-NER

Fanconi Anemia Pathway

Regulation of TP53 Activity through Phosphorylation

Activation of the pre-replicative complex

Removal of the Flap Intermediate

G2/M DNA damage checkpoint

Meiotic recombination

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000012061	ERCC1 / P07992 / ERCC excision repair 1, endonuclease non-catalytic subunit	/ reaction / complex
ENSG00000094804	CDC6 / Q99741 / cell division cycle 6	/ reaction / complex
ENSG00000106399	RPA3 / P35244 / replication protein A3	/ complex
ENSG00000101751	POLI / Q9UNA4 / DNA polymerase iota	/ reaction / complex
ENSG00000106628	POLD2 / P49005 / DNA polymerase delta 2, accessory subunit	/ reaction / complex
ENSG00000100823	APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1	/ complex / reaction
ENSG00000122008	POLK / Q9UBT6 / DNA polymerase kappa	/ complex / reaction
ENSG00000097046	CDC7 / O00311 / cell division cycle 7	/ complex / reaction
ENSG00000070010	UFD1 / Q92890 / ubiquitin recognition factor in ER associated degradation 1	/ complex / reaction
ENSG00000006634	DBF4 / Q9UBU7 / DBF4 zinc finger	/ reaction / complex
ENSG00000136492	BRIP1 / Q9BX63 / BRCA1 interacting protein C-terminal helicase 1	/ complex / reaction
ENSG00000077514	POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit	/ reaction / complex
ENSG00000005156	LIG3 / P49916 / DNA ligase 3	/ reaction
ENSG00000123374	CDK2 / P24941 / cyclin dependent kinase 2	/ reaction / complex
ENSG00000073050	XRCC1 / P18887 / X-ray repair cross complementing 1	/ reaction
ENSG00000135945	REV1 / Q9UBZ9 / REV1, DNA directed polymerase	/ reaction / complex
ENSG00000093009	CDC45 / O75419 / cell division cycle 45	/ complex / reaction
ENSG00000104320	NBN / nibrin / O60934	/ reaction / complex
ENSG00000138376	BARD1 / Q99728 / BRCA1 associated RING domain 1	/ reaction / complex
ENSG00000105486	LIG1 / P18858 / DNA ligase 1	/ complex / reaction
ENSG00000014138	POLA2 / Q14181 / DNA polymerase alpha 2, accessory subunit	/ reaction / complex
ENSG00000154914	USP43 / Q70EL4 / ubiquitin specific peptidase 43	/ complex / reaction
ENSG00000175643	RMI2 / Q96E14 / RecQ mediated genome instability 2	/ complex / reaction
ENSG00000175482	POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit	/ reaction / complex
ENSG00000114742	WDR48 / Q8TAF3 / WD repeat domain 48	/ complex / reaction
ENSG00000144554	FANCD2 / Q9BXW9 / Fanconi anemia complementation group D2	/ reaction / complex
ENSG00000165392	WRN / Q14191 / Werner syndrome RecQ like helicase	/ complex / reaction
ENSG00000140525	FANCI / Q9NVI1 / Fanconi anemia complementation group I	/ reaction / complex
ENSG00000149923	PPP4C / P60510 / protein phosphatase 4 catalytic subunit	/ reaction
ENSG00000175595	ERCC4 / Q92889 / ERCC excision repair 4, endonuclease catalytic subunit	/ reaction / complex
ENSG00000070950	RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase	/ complex / reaction
ENSG00000116670	MAD2L2 / Q9UI95 / mitotic arrest deficient 2 like 2	/ complex / reaction
ENSG00000164053	ATRIP / Q8WXE1 / ATR interacting protein	/ reaction / complex
ENSG00000168496	FEN1 / P39748 / flap structure-specific endonuclease 1	/ complex / reaction
ENSG00000151164	RAD9B / Q6WBX8 / RAD9 checkpoint clamp component B	/ complex / reaction
ENSG00000182179	UBA7 / P41226 / ubiquitin like modifier activating enzyme 7	/ reaction
ENSG00000136273	HUS1 / O60921 / HUS1 checkpoint clamp component	/ reaction / complex
ENSG00000121060	Q14258 / TRIM25 / tripartite motif containing 25	/ reaction / complex
ENSG00000185122	HSF1 / Q00613 / heat shock transcription factor 1	/ reaction / complex
ENSG00000139842	CUL4A / Q13619 / cullin 4A	/ reaction / complex
ENSG00000172613	RAD9A / Q99638 / RAD9 checkpoint clamp component A	/ complex / reaction
ENSG00000009413	REV3L / O60673 / REV3 like, DNA directed polymerase zeta catalytic subunit	/ reaction / complex
ENSG00000143476	DTL / Q9NZJ0 / denticleless E3 ubiquitin protein ligase homolog	/ reaction / complex
ENSG00000070501	POLB / P06746 / DNA polymerase beta	/ reaction
ENSG00000100387	RBX1 / P62877 / ring-box 1	/ reaction / complex
ENSG00000158290	CUL4B / Q13620 / cullin 4B	/ reaction / complex
ENSG00000132383	RPA1 / P27694 / replication protein A1	/ complex
ENSG00000132646	PCNA / P12004 / proliferating cell nuclear antigen	/ complex / reaction
ENSG00000187608	ISG15 / P05161 / ISG15 ubiquitin-like modifier	/ reaction / complex
ENSG00000170734	POLH / Q9Y253 / DNA polymerase eta	/ complex / reaction
ENSG00000010072	SPRTN / Q9H040 / SprT-like N-terminal domain	/ reaction / complex
ENSG00000062822	POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit	/ complex / reaction
ENSG00000175054	ATR / Q13535 / ATR serine/threonine kinase	/ complex / reaction
ENSG00000119048	UBE2B / P63146 / ubiquitin conjugating enzyme E2 B	/ complex / reaction
ENSG00000113456	RAD1 / O60671 / RAD1 checkpoint DNA exonuclease	/ reaction / complex
ENSG00000167986	DDB1 / Q16531 / damage specific DNA binding protein 1	/ complex / reaction
ENSG00000134899	ERCC5 / P28715 / ERCC excision repair 5, endonuclease	/ complex / reaction
ENSG00000156587	O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6	/ reaction / complex
ENSG00000146143	PRIM2 / P49643 / DNA primase subunit 2	/ reaction / complex
ENSG00000149311	ATM / Q13315 / ATM serine/threonine kinase	/ reaction / complex
ENSG00000178966	RMI1 / Q9H9A7 / RecQ mediated genome instability 1	/ complex / reaction
ENSG00000198056	PRIM1 / P49642 / DNA primase subunit 1	/ complex / reaction
ENSG00000020922	MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease	/ reaction / complex
ENSG00000177302	TOP3A / Q13472 / DNA topoisomerase III alpha	/ complex / reaction
ENSG00000162607	USP1 / O94782 / ubiquitin specific peptidase 1	/ reaction / complex
ENSG00000182446	NPLOC4 / Q8TAT6 / NPL4 homolog, ubiquitin recognition factor	/ reaction / complex
ENSG00000172977	KAT5 / Q92993 / lysine acetyltransferase 5	/ reaction / complex
ENSG00000101773	RBBP8 / Q99708 / RB binding protein 8, endonuclease	/ reaction / complex
ENSG00000138346	DNA2 / P51530 / DNA replication helicase/nuclease 2	/ reaction / complex
ENSG00000012048	BRCA1 / P38398 / BRCA1, DNA repair associated	/ complex / reaction
ENSG00000174371	EXO1 / Q9UQ84 / exonuclease 1	/ complex / reaction
ENSG00000163605	PPP4R2 / Q9NY27 / protein phosphatase 4 regulatory subunit 2	/ reaction
ENSG00000165280	VCP / P55072 / valosin containing protein	/ complex / reaction
ENSG00000197299	BLM / P54132 / Bloom syndrome RecQ like helicase	/ complex / reaction
ENSG00000077152	UBE2T / Q9NPD8 / ubiquitin conjugating enzyme E2 T	/ reaction / complex
ENSG00000204086	RPA4 / Q13156 / replication protein A4	/ complex
ENSG00000101868	POLA1 / P09884 / DNA polymerase alpha 1, catalytic subunit	/ complex / reaction
ENSG00000065328	MCM10 / Q7L590 / minichromosome maintenance 10 replication initiation factor	/ complex / reaction
ENSG00000113522	RAD50 / Q92878 / RAD50 double strand break repair protein	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr