ENSG00000146143


Homo sapiens

Features
Gene ID: ENSG00000146143
  
Biological name :PRIM2
  
Synonyms : DNA primase subunit 2 / P49643 / PRIM2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p11.2
Gene start: 57314805
Gene end: 57646849
  
Corresponding Affymetrix probe sets: 1554884_at (Human Genome U133 Plus 2.0 Array)   1554885_a_at (Human Genome U133 Plus 2.0 Array)   205628_at (Human Genome U133 Plus 2.0 Array)   215708_s_at (Human Genome U133 Plus 2.0 Array)   215709_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000485304
Ensembl peptide - ENSP00000485395
Ensembl peptide - ENSP00000483201
Ensembl peptide - ENSP00000484105
NCBI entrez gene - 5558     See in Manteia.
OMIM - 176636
RefSeq - XM_017011007
RefSeq - NM_000947
RefSeq - NM_001282487
RefSeq - NM_001282488
RefSeq - XM_017011004
RefSeq - XM_017011005
RefSeq - XM_017011006
RefSeq Peptide - NP_001269417
RefSeq Peptide - NP_000938
RefSeq Peptide - NP_001269416
swissprot - A0A096LP51
swissprot - P49643
swissprot - A0A024RD43
Ensembl - ENSG00000146143
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prim2ENSDARG00000052721Danio rerio
 PRIM2ENSGALG00000016278Gallus gallus
 Prim2ENSMUSG00000026134Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007238  DNA primase large subunit, eukaryotic/archaeal
 IPR016558  DNA primase, large subunit, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006269 DNA replication, synthesis of RNA primer IEA
 biological_processGO:0006270 DNA replication initiation TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IBA
 molecular_functionGO:0003896 DNA primase activity IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100479 POLE2 / P56282 / DNA polymerase epsilon 2, accessory subunit  / complex / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction / complex
 ENSG00000115350 POLE4 / Q9NR33 / DNA polymerase epsilon 4, accessory subunit  / reaction / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction / complex
 ENSG00000014138 POLA2 / Q14181 / DNA polymerase alpha 2, accessory subunit  / reaction / complex
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000198056 PRIM1 / P49642 / DNA primase subunit 1  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / complex / reaction
 ENSG00000146143 PRIM2 / P49643 / DNA primase subunit 2  / reaction
 ENSG00000101868 POLA1 / P09884 / DNA polymerase alpha 1, catalytic subunit  / complex / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000168496 FEN1 / P39748 / flap structure-specific endonuclease 1  / reaction
 ENSG00000177084 POLE / Q07864 / DNA polymerase epsilon, catalytic subunit  / complex / reaction
 ENSG00000138346 DNA2 / P51530 / DNA replication helicase/nuclease 2  / complex / reaction
 ENSG00000148229 POLE3 / Q9NRF9 / DNA polymerase epsilon 3, accessory subunit  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex






 

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