ENSG00000014138


Homo sapiens

Features
Gene ID: ENSG00000014138
  
Biological name :POLA2
  
Synonyms : DNA polymerase alpha 2, accessory subunit / POLA2 / Q14181
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 65261762
Gene end: 65305589
  
Corresponding Affymetrix probe sets: 204441_s_at (Human Genome U133 Plus 2.0 Array)   236546_at (Human Genome U133 Plus 2.0 Array)   244575_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433952
Ensembl peptide - ENSP00000434173
Ensembl peptide - ENSP00000265465
Ensembl peptide - ENSP00000432536
NCBI entrez gene - 23649     See in Manteia.
RefSeq - XM_017017452
RefSeq - NM_002689
RefSeq - XM_011544877
RefSeq - XM_011544878
RefSeq - XM_011544879
RefSeq - XM_011544881
RefSeq Peptide - NP_002680
swissprot - E9PQ99
swissprot - H0YDR7
swissprot - E9PIQ6
swissprot - Q14181
Ensembl - ENSG00000014138
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pola2ENSDARG00000015070Danio rerio
 Pola2ENSMUSG00000024833Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007185  DNA polymerase alpha/epsilon, subunit B
 IPR013627  DNA polymerase alpha, subunit B N-terminal
 IPR016722  DNA polymerase alpha, subunit B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100479 POLE2 / P56282 / DNA polymerase epsilon 2, accessory subunit  / complex / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction / complex
 ENSG00000115350 POLE4 / Q9NR33 / DNA polymerase epsilon 4, accessory subunit  / complex / reaction
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction / complex
 ENSG00000101868 POLA1 / P09884 / DNA polymerase alpha 1, catalytic subunit  / complex / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / reaction / complex
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000146143 PRIM2 / P49643 / DNA primase subunit 2  / reaction / complex
 ENSG00000198056 PRIM1 / P49642 / DNA primase subunit 1  / reaction / complex
 ENSG00000014138 POLA2 / Q14181 / DNA polymerase alpha 2, accessory subunit  / reaction
 ENSG00000168496 FEN1 / P39748 / flap structure-specific endonuclease 1  / reaction
 ENSG00000177084 POLE / Q07864 / DNA polymerase epsilon, catalytic subunit  / reaction / complex
 ENSG00000138346 DNA2 / P51530 / DNA replication helicase/nuclease 2  / complex / reaction
 ENSG00000148229 POLE3 / Q9NRF9 / DNA polymerase epsilon 3, accessory subunit  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex






 

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