Manteia

ENSG00000175482

Homo sapiens

Features

Gene ID:	ENSG00000175482

Biological name :	POLD4

Synonyms :	DNA polymerase delta 4, accessory subunit / POLD4 / Q9HCU8

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	11
Strand:	-1
Band:	q13.2
Gene start:	67350777
Gene end:	67356972

Corresponding Affymetrix probe sets:	202996_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000436361 Ensembl peptide - ENSP00000481251 Ensembl peptide - ENSP00000479678 Ensembl peptide - ENSP00000444780 Ensembl peptide - ENSP00000311368 Ensembl peptide - ENSP00000433408 NCBI entrez gene - 57804 See in Manteia. OMIM - 611525 RefSeq - NM_001256870 RefSeq - NM_021173 RefSeq Peptide - NP_001243799 RefSeq Peptide - NP_066996 swissprot - Q9HCU8 swissprot - A0A024R5D7 swissprot - E9PL15 Ensembl - ENSG00000175482

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
si:dkey-28b4.7	ENSDARG00000079632	Danio rerio
Pold4	ENSMUSG00000024854	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
AP003419.1	ENSG00000256514	71

Protein motifs (from Interpro)

Interpro ID	Name
IPR007218	DNA polymerase delta, subunit 4

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000723	telomere maintenance	TAS
biological_process	GO:0000731	DNA synthesis involved in DNA repair	IBA
biological_process	GO:0006260	DNA replication	IEA
biological_process	GO:0006261	DNA-dependent DNA replication	IBA
biological_process	GO:0006266	DNA ligation	TAS
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006283	transcription-coupled nucleotide-excision repair	TAS
biological_process	GO:0006296	nucleotide-excision repair, DNA incision, 5"-to lesion	TAS
biological_process	GO:0006297	nucleotide-excision repair, DNA gap filling	TAS
biological_process	GO:0006298	mismatch repair	TAS
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0019985	translesion synthesis	TAS
biological_process	GO:0032201	telomere maintenance via semi-conservative replication	TAS
biological_process	GO:0033683	nucleotide-excision repair, DNA incision	TAS
biological_process	GO:0042769	DNA damage response, detection of DNA damage	TAS
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005730	nucleolus	IDA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0043625	delta DNA polymerase complex	IBA
molecular_function	GO:0003887	DNA-directed DNA polymerase activity	TAS
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Recognition of DNA damage by PCNA-containing replication complex

Polymerase switching on the C-strand of the telomere

Processive synthesis on the C-strand of the telomere

Telomere C-strand (Lagging Strand) Synthesis

Removal of the Flap Intermediate from the C-strand

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

PCNA-Dependent Long Patch Base Excision Repair

Termination of translesion DNA synthesis

HDR through Homologous Recombination (HRR)

Gap-filling DNA repair synthesis and ligation in GG-NER

Dual Incision in GG-NER

Dual incision in TC-NER

Gap-filling DNA repair synthesis and ligation in TC-NER

Polymerase switching

Removal of the Flap Intermediate

Processive synthesis on the lagging strand

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000106399	RPA3 / P35244 / replication protein A3	/ complex / reaction
ENSG00000106628	POLD2 / P49005 / DNA polymerase delta 2, accessory subunit	/ reaction / complex
ENSG00000100823	APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1	/ complex / reaction
ENSG00000077514	POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit	/ reaction / complex
ENSG00000005156	LIG3 / P49916 / DNA ligase 3	/ reaction
ENSG00000073050	XRCC1 / P18887 / X-ray repair cross complementing 1	/ reaction
ENSG00000132383	RPA1 / P27694 / replication protein A1	/ complex / reaction
ENSG00000105486	LIG1 / P18858 / DNA ligase 1	/ complex / reaction
ENSG00000014138	POLA2 / Q14181 / DNA polymerase alpha 2, accessory subunit	/ reaction / complex
ENSG00000100387	RBX1 / P62877 / ring-box 1	/ reaction / complex
ENSG00000143476	DTL / Q9NZJ0 / denticleless E3 ubiquitin protein ligase homolog	/ complex / reaction
ENSG00000168496	FEN1 / P39748 / flap structure-specific endonuclease 1	/ reaction / complex
ENSG00000198056	PRIM1 / P49642 / DNA primase subunit 1	/ reaction / complex
ENSG00000119048	UBE2B / P63146 / ubiquitin conjugating enzyme E2 B	/ reaction / complex
ENSG00000101868	POLA1 / P09884 / DNA polymerase alpha 1, catalytic subunit	/ reaction / complex
ENSG00000167986	DDB1 / Q16531 / damage specific DNA binding protein 1	/ complex / reaction
ENSG00000146143	PRIM2 / P49643 / DNA primase subunit 2	/ reaction / complex
ENSG00000062822	POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit	/ complex / reaction
ENSG00000175482	POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit	/ reaction
ENSG00000139842	CUL4A / Q13619 / cullin 4A	/ complex / reaction
ENSG00000158290	CUL4B / Q13620 / cullin 4B	/ complex / reaction
ENSG00000070501	POLB / P06746 / DNA polymerase beta	/ reaction
ENSG00000070950	RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase	/ complex / reaction
ENSG00000132646	PCNA / P12004 / proliferating cell nuclear antigen	/ reaction / complex
ENSG00000117748	RPA2 / P15927 / replication protein A2	/ complex / reaction
ENSG00000138346	DNA2 / P51530 / DNA replication helicase/nuclease 2	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr