ENSG00000070950


Homo sapiens

Features
Gene ID: ENSG00000070950
  
Biological name :RAD18
  
Synonyms : Q9NS91 / RAD18 / RAD18, E3 ubiquitin protein ligase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p25.3
Gene start: 8775402
Gene end: 8963773
  
Corresponding Affymetrix probe sets: 223417_at (Human Genome U133 Plus 2.0 Array)   224200_s_at (Human Genome U133 Plus 2.0 Array)   238670_at (Human Genome U133 Plus 2.0 Array)   238748_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402049
Ensembl peptide - ENSP00000412261
Ensembl peptide - ENSP00000412054
Ensembl peptide - ENSP00000264926
Ensembl peptide - ENSP00000393783
Ensembl peptide - ENSP00000397852
Ensembl peptide - ENSP00000399620
NCBI entrez gene - 56852     See in Manteia.
OMIM - 605256
RefSeq - NM_020165
RefSeq - XM_017006873
RefSeq Peptide - NP_064550
swissprot - C9J0Q4
swissprot - H7C3I2
swissprot - Q9NS91
swissprot - H7C0A5
swissprot - F8WAZ7
swissprot - F8WE49
swissprot - F8WFA6
Ensembl - ENSG00000070950
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad18ENSDARG00000027938Danio rerio
 RAD18ENSGALG00000008368Gallus gallus
 Rad18ENSMUSG00000030254Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003034  SAP domain
 IPR006642  Zinc finger, Rad18-type putative
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006301 postreplication repair IBA
 biological_processGO:0006513 protein monoubiquitination IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009411 response to UV IBA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0051984 positive regulation of chromosome segregation IMP
 biological_processGO:0060548 negative regulation of cell death IDA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0035861 site of double-strand break IDA
 cellular_componentGO:0042405 nuclear inclusion body IDA
 cellular_componentGO:0097505 Rad6-Rad18 complex IBA
 molecular_functionGO:0000403 Y-form DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity IBA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / complex / reaction
 ENSG00000119048 UBE2B / P63146 / ubiquitin conjugating enzyme E2 B  / complex
 ENSG00000070950 RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase  / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000146414 SHPRH / Q149N8 / SNF2 histone linker PHD RING helicase  / reaction / complex
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / complex / reaction
 ENSG00000071794 HLTF / Q14527 / helicase like transcription factor  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / reaction / complex
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / complex / reaction






 

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