ENSG00000146414


Homo sapiens

Features
Gene ID: ENSG00000146414
  
Biological name :SHPRH
  
Synonyms : Q149N8 / SHPRH / SNF2 histone linker PHD RING helicase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q24.3
Gene start: 145864245
Gene end: 145964423
  
Corresponding Affymetrix probe sets: 226366_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430528
Ensembl peptide - ENSP00000429548
Ensembl peptide - ENSP00000486723
Ensembl peptide - ENSP00000275233
Ensembl peptide - ENSP00000356473
Ensembl peptide - ENSP00000356475
Ensembl peptide - ENSP00000403790
Ensembl peptide - ENSP00000408019
Ensembl peptide - ENSP00000412797
NCBI entrez gene - 257218     See in Manteia.
OMIM - 608048
RefSeq - XM_017010696
RefSeq - XM_006715443
RefSeq - XM_011535719
RefSeq - XM_011535722
RefSeq - XM_017010691
RefSeq - XM_017010692
RefSeq - XM_017010693
RefSeq - XM_017010694
RefSeq - XM_017010695
RefSeq - NM_001042683
RefSeq - NM_173082
RefSeq - XM_006715439
RefSeq - XM_006715441
RefSeq Peptide - NP_775105
RefSeq Peptide - NP_001036148
swissprot - K4DI94
swissprot - Q5JT88
swissprot - A0A0D9SFM0
swissprot - H0YBI0
swissprot - Q149N8
swissprot - H7C2W2
Ensembl - ENSG00000146414
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shprhENSDARG00000075884Danio rerio
 SHPRHENSGALG00000012289Gallus gallus
 ShprhENSMUSG00000090112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR005818  Linker histone H1/H5, domain H15
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0016567 protein ubiquitination TAS
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity EXP


Pathways (from Reactome)
Pathway description
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070950 RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000119048 UBE2B / P63146 / ubiquitin conjugating enzyme E2 B  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / complex / reaction






 

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