ENSG00000119048


Homo sapiens

Features
Gene ID: ENSG00000119048
  
Biological name :UBE2B
  
Synonyms : P63146 / UBE2B / ubiquitin conjugating enzyme E2 B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q31.1
Gene start: 134371179
Gene end: 134391992
  
Corresponding Affymetrix probe sets: 202333_s_at (Human Genome U133 Plus 2.0 Array)   202334_s_at (Human Genome U133 Plus 2.0 Array)   202335_s_at (Human Genome U133 Plus 2.0 Array)   211763_s_at (Human Genome U133 Plus 2.0 Array)   224118_at (Human Genome U133 Plus 2.0 Array)   228588_s_at (Human Genome U133 Plus 2.0 Array)   239163_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425237
Ensembl peptide - ENSP00000426364
Ensembl peptide - ENSP00000265339
Ensembl peptide - ENSP00000425137
NCBI entrez gene - 7320     See in Manteia.
OMIM - 179095
RefSeq - NM_003337
RefSeq Peptide - NP_003328
swissprot - D6RDW8
swissprot - H0Y9V2
swissprot - H0YA80
swissprot - P63146
Ensembl - ENSG00000119048
  
Related genetic diseases (OMIM): 179095 - ?Male infertility
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UBE2BENSGALG00000032664Gallus gallus
 Ube2bENSMUSG00000020390Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBE2A / P49459 / ubiquitin conjugating enzyme E2 AENSG0000007772195
UBE2U / Q5VVX9 / ubiquitin conjugating enzyme E2 U (putative)ENSG0000017741430


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IMP
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006281 DNA repair IGI
 biological_processGO:0006301 postreplication repair NAS
 biological_processGO:0006344 maintenance of chromatin silencing IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process NAS
 biological_processGO:0006513 protein monoubiquitination IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007288 sperm axoneme assembly IEA
 biological_processGO:0009411 response to UV IGI
 biological_processGO:0010845 positive regulation of reciprocal meiotic recombination IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0031056 regulation of histone modification IEA
 biological_processGO:0033128 negative regulation of histone phosphorylation IEA
 biological_processGO:0033522 histone H2A ubiquitination IMP
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IDA
 biological_processGO:0045141 meiotic telomere clustering IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051026 chiasma assembly IEA
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0070076 histone lysine demethylation IEA
 biological_processGO:0070193 synaptonemal complex organization IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IDA
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0001741 XY body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0033503 HULC complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / complex / reaction
 ENSG00000119048 UBE2B / P63146 / ubiquitin conjugating enzyme E2 B  / complex
 ENSG00000070950 RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase  / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000146414 SHPRH / Q149N8 / SNF2 histone linker PHD RING helicase  / complex / reaction
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / complex / reaction
 ENSG00000071794 HLTF / Q14527 / helicase like transcription factor  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / complex / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / reaction / complex






 

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