ENSG00000071794


Homo sapiens

Features
Gene ID: ENSG00000071794
  
Biological name :HLTF
  
Synonyms : helicase like transcription factor / HLTF / Q14527
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q24
Gene start: 149030127
Gene end: 149086554
  
Corresponding Affymetrix probe sets: 202983_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000308944
Ensembl peptide - ENSP00000420106
Ensembl peptide - ENSP00000420429
Ensembl peptide - ENSP00000420745
Ensembl peptide - ENSP00000376644
NCBI entrez gene - 6596     See in Manteia.
OMIM - 603257
RefSeq - XM_017007079
RefSeq - NM_001318935
RefSeq - NM_003071
RefSeq - NM_139048
RefSeq - XM_011513091
RefSeq - XM_011513092
RefSeq - XM_011513093
RefSeq - XM_017007078
RefSeq - NM_001318934
RefSeq Peptide - NP_620636
RefSeq Peptide - NP_001305863
RefSeq Peptide - NP_001305864
RefSeq Peptide - NP_003062
swissprot - Q14527
swissprot - H7C5K0
swissprot - A0A0C4DGA6
Ensembl - ENSG00000071794
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hltfENSDARG00000026053Danio rerio
 HltfENSMUSG00000002428Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014905  HIRAN domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity EXP


Pathways (from Reactome)
Pathway description
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000119048 UBE2B / P63146 / ubiquitin conjugating enzyme E2 B  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000070950 RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / complex / reaction






 

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