ENSMUSG00000002428


Mus musculus

Features
Gene ID: ENSMUSG00000002428
  
Biological name :Hltf
  
Synonyms : Helicase-like transcription factor / Hltf / Q6PCN7
  
Possible biological names infered from orthology : Q14527
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A2
Gene start: 20057811
Gene end: 20118490
  
Corresponding Affymetrix probe sets: 10491014 (MoGene1.0st)   1425996_a_at (Mouse Genome 430 2.0 Array)   1450889_at (Mouse Genome 430 2.0 Array)   1451901_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118775
Ensembl peptide - ENSMUSP00000002502
Ensembl peptide - ENSMUSP00000116570
NCBI entrez gene - 20585     See in Manteia.
MGI - MGI:1196437
RefSeq - XM_006535429
RefSeq - XM_006535428
RefSeq - NM_009210
RefSeq Peptide - NP_033236
RefSeq Peptide - NP_001342026
swissprot - Q6PCN7
swissprot - G3UVU1
swissprot - E9PVX5
Ensembl - ENSMUSG00000002428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hltfENSDARG00000026053Danio rerio
 HLTFENSG00000071794Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014905  HIRAN domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0014178 increased brain apoptosis "increase in the number of cells of the brain undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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