ENSG00000132383


Homo sapiens

Features
Gene ID: ENSG00000132383
  
Biological name :RPA1
  
Synonyms : P27694 / replication protein A1 / RPA1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.3
Gene start: 1829702
Gene end: 1900082
  
Corresponding Affymetrix probe sets: 201528_at (Human Genome U133 Plus 2.0 Array)   201529_s_at (Human Genome U133 Plus 2.0 Array)   236675_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459788
Ensembl peptide - ENSP00000254719
Ensembl peptide - ENSP00000461466
Ensembl peptide - ENSP00000461733
NCBI entrez gene - 6117     See in Manteia.
OMIM - 179835
RefSeq - NM_001355120
RefSeq - NM_002945
RefSeq Peptide - NP_001342049
RefSeq Peptide - NP_002936
swissprot - P27694
swissprot - I3L2M5
swissprot - I3L4R8
swissprot - I3L524
Ensembl - ENSG00000132383
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpa1ENSDARG00000003938Danio rerio
 RPA1ENSGALG00000003072Gallus gallus
 Rpa1ENSMUSG00000000751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004365  OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
 IPR004591  Replication factor A protein 1
 IPR007199  Replication factor-A protein 1, N-terminal
 IPR012340  Nucleic acid-binding, OB-fold
 IPR013955  Replication factor A, C-terminal
 IPR031657  Replication protein A, OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000723 telomere maintenance IC
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006261 DNA-dependent DNA replication TAS
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006284 base-excision repair IDA
 biological_processGO:0006289 nucleotide-excision repair IMP
 biological_processGO:0006293 nucleotide-excision repair, preincision complex stabilization TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling TAS
 biological_processGO:0006298 mismatch repair TAS
 biological_processGO:0006310 DNA recombination TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0034502 protein localization to chromosome IDA
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0042276 error-prone translesion synthesis TAS
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0070987 error-free translesion synthesis TAS
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005662 DNA replication factor A complex IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IMP


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
SUMOylation of DNA damage response and repair proteins
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000012061 ERCC1 / P07992 / ERCC excision repair 1, endonuclease non-catalytic subunit  / complex / reaction
 ENSG00000094804 CDC6 / Q99741 / cell division cycle 6  / reaction / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex
 ENSG00000101751 POLI / Q9UNA4 / DNA polymerase iota  / complex / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction / complex
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / complex / reaction
 ENSG00000122008 POLK / Q9UBT6 / DNA polymerase kappa  / complex / reaction
 ENSG00000097046 CDC7 / O00311 / cell division cycle 7  / complex / reaction
 ENSG00000070010 UFD1 / Q92890 / ubiquitin recognition factor in ER associated degradation 1  / complex / reaction
 ENSG00000006634 DBF4 / Q9UBU7 / DBF4 zinc finger  / reaction / complex
 ENSG00000136492 BRIP1 / Q9BX63 / BRCA1 interacting protein C-terminal helicase 1  / reaction / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction / complex
 ENSG00000005156 LIG3 / P49916 / DNA ligase 3  / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000073050 XRCC1 / P18887 / X-ray repair cross complementing 1  / reaction
 ENSG00000135945 REV1 / Q9UBZ9 / REV1, DNA directed polymerase  / complex / reaction
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / complex / reaction
 ENSG00000010072 SPRTN / Q9H040 / SprT-like N-terminal domain  / reaction / complex
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / complex / reaction
 ENSG00000009413 REV3L / O60673 / REV3 like, DNA directed polymerase zeta catalytic subunit  / complex / reaction
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / reaction / complex
 ENSG00000070501 POLB / P06746 / DNA polymerase beta  / reaction
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / complex / reaction
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / reaction / complex
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000143476 DTL / Q9NZJ0 / denticleless E3 ubiquitin protein ligase homolog  / reaction / complex
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction / complex
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / complex / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000170734 POLH / Q9Y253 / DNA polymerase eta  / reaction / complex
 ENSG00000119048 UBE2B / P63146 / ubiquitin conjugating enzyme E2 B  / reaction / complex
 ENSG00000070950 RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000172613 RAD9A / Q99638 / RAD9 checkpoint clamp component A  / complex / reaction
 ENSG00000136273 HUS1 / O60921 / HUS1 checkpoint clamp component  / reaction / complex
 ENSG00000116670 MAD2L2 / Q9UI95 / mitotic arrest deficient 2 like 2  / complex / reaction
 ENSG00000164053 ATRIP / Q8WXE1 / ATR interacting protein  / reaction / complex
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / complex / reaction
 ENSG00000151164 RAD9B / Q6WBX8 / RAD9 checkpoint clamp component B  / reaction / complex
 ENSG00000182179 UBA7 / P41226 / ubiquitin like modifier activating enzyme 7  / reaction
 ENSG00000168496 FEN1 / P39748 / flap structure-specific endonuclease 1  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction / complex
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000134899 ERCC5 / P28715 / ERCC excision repair 5, endonuclease  / complex / reaction
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / complex / reaction
 ENSG00000113456 RAD1 / O60671 / RAD1 checkpoint DNA exonuclease  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000093009 CDC45 / O75419 / cell division cycle 45  / complex / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000138376 BARD1 / Q99728 / BRCA1 associated RING domain 1  / reaction / complex
 ENSG00000105486 LIG1 / P18858 / DNA ligase 1  / complex / reaction
 ENSG00000014138 POLA2 / Q14181 / DNA polymerase alpha 2, accessory subunit  / complex / reaction
 ENSG00000154914 USP43 / Q70EL4 / ubiquitin specific peptidase 43  / reaction / complex
 ENSG00000175643 RMI2 / Q96E14 / RecQ mediated genome instability 2  / complex / reaction
 ENSG00000114742 WDR48 / Q8TAF3 / WD repeat domain 48  / reaction / complex
 ENSG00000144554 FANCD2 / Q9BXW9 / Fanconi anemia complementation group D2  / complex / reaction
 ENSG00000165392 WRN / Q14191 / Werner syndrome RecQ like helicase  / reaction / complex
 ENSG00000140525 FANCI / Q9NVI1 / Fanconi anemia complementation group I  / reaction / complex
 ENSG00000149923 PPP4C / P60510 / protein phosphatase 4 catalytic subunit  / reaction
 ENSG00000175595 ERCC4 / Q92889 / ERCC excision repair 4, endonuclease catalytic subunit  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex
 ENSG00000146143 PRIM2 / P49643 / DNA primase subunit 2  / reaction / complex
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction / complex
 ENSG00000178966 RMI1 / Q9H9A7 / RecQ mediated genome instability 1  / complex / reaction
 ENSG00000198056 PRIM1 / P49642 / DNA primase subunit 1  / complex / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction / complex
 ENSG00000177302 TOP3A / Q13472 / DNA topoisomerase III alpha  / complex / reaction
 ENSG00000162607 USP1 / O94782 / ubiquitin specific peptidase 1  / complex / reaction
 ENSG00000182446 NPLOC4 / Q8TAT6 / NPL4 homolog, ubiquitin recognition factor  / complex / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / reaction / complex
 ENSG00000138346 DNA2 / P51530 / DNA replication helicase/nuclease 2  / reaction / complex
 ENSG00000012048 BRCA1 / P38398 / BRCA1, DNA repair associated  / reaction / complex
 ENSG00000174371 EXO1 / Q9UQ84 / exonuclease 1  / complex / reaction
 ENSG00000163605 PPP4R2 / Q9NY27 / protein phosphatase 4 regulatory subunit 2  / reaction
 ENSG00000165280 VCP / P55072 / valosin containing protein  / complex / reaction
 ENSG00000197299 BLM / P54132 / Bloom syndrome RecQ like helicase  / complex / reaction
 ENSG00000077152 UBE2T / Q9NPD8 / ubiquitin conjugating enzyme E2 T  / complex / reaction
 ENSG00000204086 RPA4 / Q13156 / replication protein A4  / complex
 ENSG00000101868 POLA1 / P09884 / DNA polymerase alpha 1, catalytic subunit  / reaction / complex
 ENSG00000065328 MCM10 / Q7L590 / minichromosome maintenance 10 replication initiation factor  / reaction / complex
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction / complex






 

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