ENSG00000136273


Homo sapiens

Features
Gene ID: ENSG00000136273
  
Biological name :HUS1
  
Synonyms : HUS1 / HUS1 checkpoint clamp component / O60921
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p12.3
Gene start: 47695730
Gene end: 47979581
  
Corresponding Affymetrix probe sets: 204883_s_at (Human Genome U133 Plus 2.0 Array)   204884_s_at (Human Genome U133 Plus 2.0 Array)   217618_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403844
Ensembl peptide - ENSP00000416588
Ensembl peptide - ENSP00000405175
Ensembl peptide - ENSP00000404855
Ensembl peptide - ENSP00000404348
Ensembl peptide - ENSP00000258774
Ensembl peptide - ENSP00000398806
Ensembl peptide - ENSP00000400727
NCBI entrez gene - 3364     See in Manteia.
OMIM - 603760
RefSeq - NM_004507
RefSeq - XM_017012115
RefSeq Peptide - NP_004498
swissprot - C9JCK8
swissprot - O60921
swissprot - H7C272
swissprot - C9JA95
swissprot - A4D2F2
swissprot - F8WAW9
Ensembl - ENSG00000136273
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000039589Gallus gallus
 Hus1ENSMUSG00000020413Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HUS1B / Q8NHY5 / HUS1 checkpoint clamp component BENSG0000018899649


Protein motifs (from Interpro)
Interpro ID Name
 IPR007150  Checkpoint protein Hus1/Mec3
 IPR016580  Cell cycle checkpoint, Hus1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint TAS
 biological_processGO:0000724 double-strand break repair via homologous recombination IBA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006289 nucleotide-excision repair IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus TAS
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0033314 mitotic DNA replication checkpoint IBA
 biological_processGO:0044778 meiotic DNA integrity checkpoint IBA
 biological_processGO:0071479 cellular response to ionizing radiation IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030896 checkpoint clamp complex IBA
 cellular_componentGO:0035861 site of double-strand break IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000113456 RAD1 / O60671 / RAD1 checkpoint DNA exonuclease  / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000172613 RAD9A / Q99638 / RAD9 checkpoint clamp component A  / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000151164 RAD9B / Q6WBX8 / RAD9 checkpoint clamp component B  / complex






 

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