ENSMUSG00000020413


Mus musculus

Features
Gene ID: ENSMUSG00000020413
  
Biological name :Hus1
  
Synonyms : Checkpoint protein HUS1 / Hus1 / Q8BQY8
  
Possible biological names infered from orthology : HUS1 checkpoint clamp component / O60921
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 8993137
Gene end: 9011191
  
Corresponding Affymetrix probe sets: 10384322 (MoGene1.0st)   1418308_at (Mouse Genome 430 2.0 Array)   1425366_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020683
Ensembl peptide - ENSMUSP00000114339
NCBI entrez gene - 15574     See in Manteia.
MGI - MGI:1277962
RefSeq - XM_006514531
RefSeq - NM_001303532
RefSeq - NM_001303610
RefSeq - NM_008316
RefSeq Peptide - NP_001290539
RefSeq Peptide - NP_032342
RefSeq Peptide - NP_001290461
swissprot - Q8BQY8
Ensembl - ENSMUSG00000020413
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000039589Gallus gallus
 HUS1ENSG00000136273Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hus1b / Q8K572 / Checkpoint protein HUS1B / Q8NHY5* / HUS1 checkpoint clamp component B*ENSMUSG0000007643048


Protein motifs (from Interpro)
Interpro ID Name
 IPR007150  Checkpoint protein Hus1/Mec3
 IPR016580  Cell cycle checkpoint, Hus1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint ISO
 biological_processGO:0000724 double-strand break repair via homologous recombination IDA
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0006289 nucleotide-excision repair IBA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0008156 negative regulation of DNA replication IMP
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0009790 embryo development IMP
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0033314 mitotic DNA replication checkpoint IBA
 biological_processGO:0044778 meiotic DNA integrity checkpoint IBA
 biological_processGO:0071479 cellular response to ionizing radiation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030896 checkpoint clamp complex IBA
 cellular_componentGO:0035861 site of double-strand break IBA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hus1tm1.1Rsw/Hus1tm1.1Rsw
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hus1tm1.1Rsw/Hus1tm1.1Rsw
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hus1tm1.1Rsw/Hus1tm1.1Rsw
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hus1tm1.1Rsw/Hus1tm1.1Rsw
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hus1tm1.1Rsw/Hus1tm1.1Rsw
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hus1tm1.1Rsw/Hus1tm1.1Rsw
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hus1tm1Led/Hus1tm2Rsw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004573 absent limb buds "missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0008409 increased cellular sensitivity to hydroxyurea "greater incidence of cell death following exposure to hydroxyurea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hus1tm1.1Rsw/Hus1tm1.1Rsw
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hus1tm1.1Rsw/Hus1tm1.1Rsw
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011705 absent fibroblast proliferation "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hus1tm1.1Rsw/Hus1tm1.1Rsw
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000038569 Rad9b / Q6WBX7 / RAD9 checkpoint clamp component B / Q6WBX8*  / complex
 ENSMUSG00000024824 Rad9a / Q9Z0F6 / Cell cycle checkpoint control protein RAD9A / Q99638* / RAD9 checkpoint clamp component A*  / complex
 ENSMUSG00000022248 Rad1 / Q9QWZ1 / Cell cycle checkpoint protein RAD1 / O60671* / RAD1 checkpoint DNA exonuclease*  / complex






 

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