ENSMUSG00000038569


Mus musculus

Features
Gene ID: ENSMUSG00000038569
  
Biological name :Rad9b
  
Synonyms : Q6WBX7 / Rad9b / RAD9 checkpoint clamp component B
  
Possible biological names infered from orthology : Q6WBX8
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 122323223
Gene end: 122354233
  
Corresponding Affymetrix probe sets: 10533462 (MoGene1.0st)   1425800_at (Mouse Genome 430 2.0 Array)   1439955_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120843
Ensembl peptide - ENSMUSP00000036177
Ensembl peptide - ENSMUSP00000113868
Ensembl peptide - ENSMUSP00000117334
NCBI entrez gene - 231724     See in Manteia.
MGI - MGI:2385231
RefSeq - XM_017320869
RefSeq - NM_144912
RefSeq - XM_006530305
RefSeq - XM_006530306
RefSeq - XM_006530307
RefSeq - XM_006530308
RefSeq - XM_006530310
RefSeq Peptide - NP_659161
swissprot - F6VRS2
swissprot - D3Z515
swissprot - D3Z3W7
swissprot - Q6WBX7
swissprot - Q8VC54
Ensembl - ENSMUSG00000038569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad9bENSDARG00000075632Danio rerio
 RAD9BENSG00000151164Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rad9a / Q9Z0F6 / Cell cycle checkpoint control protein RAD9A / Q99638* / RAD9 checkpoint clamp component A*ENSMUSG0000002482432


Protein motifs (from Interpro)
Interpro ID Name
 IPR007268  Rad9/Ddc1
 IPR026584  Rad9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000075 cell cycle checkpoint IEA
 biological_processGO:0000076 DNA replication checkpoint IBA
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0071479 cellular response to ionizing radiation IBA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IBA
 cellular_componentGO:0030896 checkpoint clamp complex IEA
 molecular_functionGO:0008408 3"-5" exonuclease activity IBA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Rad9btm1Lieb/Rad9b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad9btm1Lieb/Rad9b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad9btm1Lieb/Rad9b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad9btm1Lieb/Rad9b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad9btm1Lieb/Rad9b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rad9btm1Lieb/Rad9b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rad9btm1Lieb/Rad9b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Nos1tm1Plh/Nos1tm1Plh,Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rad9btm1Lieb/Rad9b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rad9btm1Lieb/Rad9b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020413 Hus1 / Q8BQY8 / Checkpoint protein HUS1 / O60921* / HUS1 checkpoint clamp component*  / complex
 ENSMUSG00000022248 Rad1 / Q9QWZ1 / Cell cycle checkpoint protein RAD1 / O60671* / RAD1 checkpoint DNA exonuclease*  / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / complex / reaction






 

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