ENSMUSG00000024824


Mus musculus

Features
Gene ID: ENSMUSG00000024824
  
Biological name :Rad9a
  
Synonyms : Cell cycle checkpoint control protein RAD9A / Q9Z0F6 / Rad9a
  
Possible biological names infered from orthology : Q99638 / RAD9 checkpoint clamp component A
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4195198
Gene end: 4201603
  
Corresponding Affymetrix probe sets: 10464659 (MoGene1.0st)   1418404_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025740
NCBI entrez gene - 19367     See in Manteia.
MGI - MGI:1328356
RefSeq - NM_011237
RefSeq Peptide - NP_035367
swissprot - Q9Z0F6
Ensembl - ENSMUSG00000024824
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad9aENSDARG00000056984Danio rerio
 RAD9AENSG00000172613Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rad9b / Q6WBX7 / RAD9 checkpoint clamp component B / Q6WBX8*ENSMUSG0000003856933


Protein motifs (from Interpro)
Interpro ID Name
 IPR007268  Rad9/Ddc1
 IPR026584  Rad9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000075 cell cycle checkpoint IEA
 biological_processGO:0000076 DNA replication checkpoint IBA
 biological_processGO:0000077 DNA damage checkpoint ISO
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0031573 intra-S DNA damage checkpoint IGI
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IBA
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0030896 checkpoint clamp complex IBA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0008853 exodeoxyribonuclease III activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Orl

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm2.1Kem/Ctnnb1+,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2.1Kem/Ctnnb1+,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Ctnnb1tm2.1Kem/Ctnnb1+,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2.1Kem/Ctnnb1+,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Ctnnb1tm2.1Kem/Ctnnb1+,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0011256 abnormal neural fold morphology "any structural anomaly of the elevated margins of the neural groove" [ISBN:0-683-40008-8]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020413 Hus1 / Q8BQY8 / Checkpoint protein HUS1 / O60921* / HUS1 checkpoint clamp component*  / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000022248 Rad1 / Q9QWZ1 / Cell cycle checkpoint protein RAD1 / O60671* / RAD1 checkpoint DNA exonuclease*  / complex






 

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