ENSG00000172613


Homo sapiens

Features
Gene ID: ENSG00000172613
  
Biological name :RAD9A
  
Synonyms : Q99638 / RAD9A / RAD9 checkpoint clamp component A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 67317871
Gene end: 67398410
  
Corresponding Affymetrix probe sets: 1562022_s_at (Human Genome U133 Plus 2.0 Array)   204828_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000311360
Ensembl peptide - ENSP00000444979
Ensembl peptide - ENSP00000445137
Ensembl peptide - ENSP00000478994
Ensembl peptide - ENSP00000442064
NCBI entrez gene - 5883     See in Manteia.
OMIM - 603761
RefSeq - XM_017018098
RefSeq - NM_001243224
RefSeq - NM_004584
RefSeq - XM_006718652
RefSeq - XM_017018097
RefSeq Peptide - NP_001230153
RefSeq Peptide - NP_004575
swissprot - F5H4F1
swissprot - F5H8A2
swissprot - Q99638
swissprot - F5H492
swissprot - A0A0G2JMD0
Ensembl - ENSG00000172613
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad9aENSDARG00000056984Danio rerio
 Rad9aENSMUSG00000024824Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAD9B / Q6WBX8 / RAD9 checkpoint clamp component BENSG0000015116434


Protein motifs (from Interpro)
Interpro ID Name
 IPR007268  Rad9/Ddc1
 IPR026584  Rad9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000075 cell cycle checkpoint IEA
 biological_processGO:0000076 DNA replication checkpoint TAS
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0031573 intra-S DNA damage checkpoint IEA
 biological_processGO:0071479 cellular response to ionizing radiation IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030896 checkpoint clamp complex IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008408 3"-5" exonuclease activity IDA
 molecular_functionGO:0008853 exodeoxyribonuclease III activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000113456 RAD1 / O60671 / RAD1 checkpoint DNA exonuclease  / complex
 ENSG00000136273 HUS1 / O60921 / HUS1 checkpoint clamp component  / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction






 

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