ENSG00000113456


Homo sapiens

Features
Gene ID: ENSG00000113456
  
Biological name :RAD1
  
Synonyms : O60671 / RAD1 / RAD1 checkpoint DNA exonuclease
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: p13.2
Gene start: 34905264
Gene end: 34918989
  
Corresponding Affymetrix probe sets: 204460_s_at (Human Genome U133 Plus 2.0 Array)   204461_x_at (Human Genome U133 Plus 2.0 Array)   210216_x_at (Human Genome U133 Plus 2.0 Array)   228535_at (Human Genome U133 Plus 2.0 Array)   235253_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000371469
Ensembl peptide - ENSP00000487478
Ensembl peptide - ENSP00000423253
Ensembl peptide - ENSP00000421007
Ensembl peptide - ENSP00000313467
Ensembl peptide - ENSP00000340879
NCBI entrez gene - 5810     See in Manteia.
OMIM - 603153
RefSeq - NM_002853
RefSeq Peptide - NP_002844
swissprot - D6R9A1
swissprot - A0A024R045
swissprot - O60671
Ensembl - ENSG00000113456
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad1ENSDARG00000040559Danio rerio
 RAD1ENSGALG00000003365Gallus gallus
 Rad1ENSMUSG00000022248Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003011  Cell cycle checkpoint protein, Rad1
 IPR003021  Rad1/Rec1/Rad17


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus TAS
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0051598 meiotic recombination checkpoint IGI
 biological_processGO:0071479 cellular response to ionizing radiation IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IDA
 cellular_componentGO:0030896 checkpoint clamp complex IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003684 damaged DNA binding TAS
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008408 3"-5" exonuclease activity IDA
 molecular_functionGO:0008853 exodeoxyribonuclease III activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000136273 HUS1 / O60921 / HUS1 checkpoint clamp component  / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000172613 RAD9A / Q99638 / RAD9 checkpoint clamp component A  / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000151164 RAD9B / Q6WBX8 / RAD9 checkpoint clamp component B  / complex






 

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