Manteia

ENSMUSG00000022248

Mus musculus

Features

Gene ID:	ENSMUSG00000022248

Biological name :	Rad1

Synonyms :	Cell cycle checkpoint protein RAD1 / Q9QWZ1 / Rad1

Possible biological names infered from orthology :	O60671 / RAD1 checkpoint DNA exonuclease

Species:	Mus musculus

Chr. number:	15
Strand:	1
Band:	A1
Gene start:	10486018
Gene end:	10499063

Corresponding Affymetrix probe sets:	10423068 (MoGene1.0st) 1448414_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000126645 Ensembl peptide - ENSMUSP00000128601 Ensembl peptide - ENSMUSP00000022856 Ensembl peptide - ENSMUSP00000132747 Ensembl peptide - ENSMUSP00000098338 NCBI entrez gene - 19355 See in Manteia. MGI - MGI:1316678 RefSeq - NM_011232 RefSeq - NM_001289447 RefSeq - NM_001289448 RefSeq Peptide - NP_001276376 RefSeq Peptide - NP_035362 RefSeq Peptide - NP_001276377 swissprot - Q9QWZ1 swissprot - E9PXK0 swissprot - E9PY19 swissprot - F7CJR1 Ensembl - ENSMUSG00000022248

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR003011	Cell cycle checkpoint protein, Rad1
IPR003021	Rad1/Rec1/Rad17

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000077	DNA damage checkpoint	IEA
biological_process	GO:0006281	DNA repair	IBA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0051598	meiotic recombination checkpoint	ISO
biological_process	GO:0071479	cellular response to ionizing radiation	ISO
biological_process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005694	chromosome	ISO
cellular_component	GO:0030896	checkpoint clamp complex	IBA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	ISO
molecular_function	GO:0003684	damaged DNA binding	IBA
molecular_function	GO:0004518	nuclease activity	IEA
molecular_function	GO:0004527	exonuclease activity	IEA
molecular_function	GO:0008408	3"-5" exonuclease activity	IBA
molecular_function	GO:0008853	exodeoxyribonuclease III activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

Activation of ATR in response to replication stress

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003795	abnormal bone structure		Show Allelic Composition: Ptpn12^{tm1b(NCOM)Mfgc}/Ptpn12^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Ptpn12^{tm1b(NCOM)Mfgc}/Tcp
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Orl
MP:0011275	abnormal behavioral response to light	"unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]	Show Allelic Composition: Ptpn12^{tm1b(NCOM)Mfgc}/Ptpn12^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Ptpn12^{tm1b(NCOM)Mfgc}/Tcp

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000028884	Rpa2 / replication protein A2 / P15927*	/ reaction / complex
ENSMUSG00000024824	Rad9a / Q9Z0F6 / Cell cycle checkpoint control protein RAD9A / Q99638* / RAD9 checkpoint clamp component A*	/ complex
ENSMUSG00000020413	Hus1 / Q8BQY8 / Checkpoint protein HUS1 / O60921* / HUS1 checkpoint clamp component*	/ complex
ENSMUSG00000038569	Rad9b / Q6WBX7 / RAD9 checkpoint clamp component B / Q6WBX8*	/ complex
ENSMUSG00000012483	Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*	/ complex / reaction
ENSMUSG00000000751	Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr