ENSG00000135945


Homo sapiens

Features
Gene ID: ENSG00000135945
  
Biological name :REV1
  
Synonyms : Q9UBZ9 / REV1 / REV1, DNA directed polymerase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q11.2
Gene start: 99400475
Gene end: 99490035
  
Corresponding Affymetrix probe sets: 218428_s_at (Human Genome U133 Plus 2.0 Array)   222628_s_at (Human Genome U133 Plus 2.0 Array)   222629_at (Human Genome U133 Plus 2.0 Array)   243592_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258428
Ensembl peptide - ENSP00000404213
Ensembl peptide - ENSP00000414875
Ensembl peptide - ENSP00000416274
Ensembl peptide - ENSP00000377091
NCBI entrez gene - 51455     See in Manteia.
OMIM - 606134
RefSeq - XM_017004315
RefSeq - NM_001321458
RefSeq - NM_001321459
RefSeq - NM_001321460
RefSeq - NM_016316
RefSeq - XM_011511341
RefSeq - XM_017004309
RefSeq - XM_017004310
RefSeq - XM_017004311
RefSeq - XM_017004312
RefSeq - XM_017004313
RefSeq - XM_017004314
RefSeq - NM_001037872
RefSeq - NM_001321454
RefSeq - NM_001321455
RefSeq Peptide - NP_001308383
RefSeq Peptide - NP_001308388
RefSeq Peptide - NP_001308389
RefSeq Peptide - NP_057400
RefSeq Peptide - NP_001032961
RefSeq Peptide - NP_001308384
RefSeq Peptide - NP_001308387
swissprot - H7C263
swissprot - C9JPS2
swissprot - F8WCR0
swissprot - Q9UBZ9
Ensembl - ENSG00000135945
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rev1ENSDARG00000018296Danio rerio
 REV1ENSGALG00000016766Gallus gallus
 Rev1ENSMUSG00000026082Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
POLI / Q9UNA4 / DNA polymerase iotaENSG0000010175112
POLK / Q9UBT6 / DNA polymerase kappaENSG0000012200812
POLH / Q9Y253 / DNA polymerase etaENSG0000017073411


Protein motifs (from Interpro)
Interpro ID Name
 IPR001126  UmuC domain
 IPR001357  BRCT domain
 IPR012112  DNA repair protein Rev1
 IPR017961  DNA polymerase, Y-family, little finger domain
 IPR025527  Domain of unknown function DUF4414
 IPR031991  DNA repair protein Rev1, C-terminal
 IPR036420  BRCT domain superfamily
 IPR036775  DNA polymerase, Y-family, little finger domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009411 response to UV IDA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0042276 error-prone translesion synthesis TAS
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0017125 deoxycytidyl transferase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122008 POLK / Q9UBT6 / DNA polymerase kappa  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000101751 POLI / Q9UNA4 / DNA polymerase iota  / complex / reaction
 ENSG00000182179 UBA7 / P41226 / ubiquitin like modifier activating enzyme 7  / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000009413 REV3L / O60673 / REV3 like, DNA directed polymerase zeta catalytic subunit  / reaction / complex
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction / complex
 ENSG00000116670 MAD2L2 / Q9UI95 / mitotic arrest deficient 2 like 2  / reaction / complex
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction






 

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