ENSG00000182179


Homo sapiens

Features
Gene ID: ENSG00000182179
  
Biological name :UBA7
  
Synonyms : P41226 / UBA7 / ubiquitin like modifier activating enzyme 7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 49805207
Gene end: 49813946
  
Corresponding Affymetrix probe sets: 1294_at (Human Genome U133 Plus 2.0 Array)   203281_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000333266
NCBI entrez gene - 7318     See in Manteia.
OMIM - 191325
RefSeq - XM_011534072
RefSeq - NM_003335
RefSeq - XM_011534070
RefSeq - XM_011534071
RefSeq - XM_005265430
RefSeq - XM_006713321
RefSeq Peptide - NP_003326
swissprot - P41226
Ensembl - ENSG00000182179
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uba7ENSDARG00000061222Danio rerio
 UBA7ENSGALG00000036263Gallus gallus
 Uba7ENSMUSG00000032596Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBA1 / P22314 / ubiquitin like modifier activating enzyme 1ENSG0000013098546
UBA6 / A0AVT1 / ubiquitin like modifier activating enzyme 6ENSG0000003317836


Protein motifs (from Interpro)
Interpro ID Name
 IPR000011  Ubiquitin/SUMO-activating enzyme E1
 IPR000594  THIF-type NAD/FAD binding fold
 IPR018075  Ubiquitin-activating enzyme E1
 IPR018965  Ubiquitin-activating enzyme E1, C-terminal
 IPR019572  Ubiquitin-activating enzyme, catalytic cysteine domain
 IPR032418  Ubiquitin-activating enzyme E1, FCCH domain
 IPR032420  Ubiquitin-activating enzyme E1, four-helix bundle
 IPR033127  Ubiquitin-activating enzyme E1, Cys active site
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IDA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019941 modification-dependent protein catabolic process IEA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0032020 ISG15-protein conjugation IEA
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004839 ubiquitin activating enzyme activity IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019782 ISG15 activating enzyme activity IDA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction
 ENSG00000101751 POLI / Q9UNA4 / DNA polymerase iota  / reaction
 ENSG00000122008 POLK / Q9UBT6 / DNA polymerase kappa  / reaction
 ENSG00000135945 REV1 / Q9UBZ9 / REV1, DNA directed polymerase  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / complex
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / reaction / complex
 ENSG00000182179 UBA7 / P41226 / ubiquitin like modifier activating enzyme 7  / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction
 ENSG00000170734 POLH / Q9Y253 / DNA polymerase eta  / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction






 

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