ENSG00000138646


Homo sapiens

Features
Gene ID: ENSG00000138646
  
Biological name :HERC5
  
Synonyms : HECT and RLD domain containing E3 ubiquitin protein ligase 5 / HERC5 / Q9UII4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q22.1
Gene start: 88457117
Gene end: 88506163
  
Corresponding Affymetrix probe sets: 219863_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264350
Ensembl peptide - ENSP00000424129
NCBI entrez gene - 51191     See in Manteia.
OMIM - 608242
RefSeq - NM_016323
RefSeq - XM_011532022
RefSeq Peptide - NP_057407
swissprot - E9PBL0
swissprot - Q9UII4
Ensembl - ENSG00000138646
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HERC5ENSDARG00000075785Danio rerio
 ENSGALG00000042001Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HERC6 / Q8IVU3 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 6ENSG0000013864249
HERC4 / Q5GLZ8 / HECT and RLD domain containing E3 ubiquitin protein ligase 4ENSG0000014863435
HERC3 / Q15034 / HECT and RLD domain containing E3 ubiquitin protein ligase 3ENSG0000013864134
UBE3A / Q05086 / ubiquitin protein ligase E3AENSG0000011406218
HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2ENSG0000012873118
HECTD2 / Q5U5R9 / HECT domain E3 ubiquitin protein ligase 2ENSG0000016533817
HERC1 / Q15751 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1ENSG0000010365717
HECTD3 / Q5T447 / HECT domain E3 ubiquitin protein ligase 3ENSG0000012610713
RCCD1 / A6NED2 / RCC1 domain containing 1ENSG000001669657
AC098582.1ENSG000002853851


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000569  HECT domain
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR035983  HECT, E3 ligase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032020 ISG15-protein conjugation IDA
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050688 regulation of defense response to virus IDA
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042296 ISG15 transferase activity IDA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / complex / reaction
 ENSG00000110321 EIF4G2 / P78344 / eukaryotic translation initiation factor 4 gamma 2  / reaction
 ENSG00000156976 EIF4A2 / Q14240 / eukaryotic translation initiation factor 4A2  / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / complex / reaction
 ENSG00000161960 EIF4A1 / P60842 / eukaryotic translation initiation factor 4A1  / reaction
 ENSG00000136068 FLNB / O75369 / filamin B  / reaction
 ENSG00000151247 EIF4E / P06730 / eukaryotic translation initiation factor 4E  / reaction
 ENSG00000075151 EIF4G3 / O43432 / eukaryotic translation initiation factor 4 gamma 3  / reaction
 ENSG00000163412 EIF4E3 / Q8N5X7 / eukaryotic translation initiation factor 4E family member 3  / reaction
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / reaction
 ENSG00000182179 UBA7 / P41226 / ubiquitin like modifier activating enzyme 7  / complex
 ENSG00000135930 EIF4E2 / O60573 / eukaryotic translation initiation factor 4E family member 2  / complex / reaction
 ENSG00000170142 P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1  / reaction
 ENSG00000138032 PPM1B / O75688 / protein phosphatase, Mg2+/Mn2+ dependent 1B  / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr