ENSG00000170142


Homo sapiens

Features
Gene ID: ENSG00000170142
  
Biological name :UBE2E1
  
Synonyms : P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p24.2
Gene start: 23805903
Gene end: 23891316
  
Corresponding Affymetrix probe sets: 212519_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411351
Ensembl peptide - ENSP00000329113
Ensembl peptide - ENSP00000475890
Ensembl peptide - ENSP00000393088
Ensembl peptide - ENSP00000410652
Ensembl peptide - ENSP00000303709
NCBI entrez gene - 7324     See in Manteia.
OMIM - 602916
RefSeq - XM_005265431
RefSeq - NM_001202476
RefSeq - NM_003341
RefSeq - NM_182666
RefSeq Peptide - NP_872607
RefSeq Peptide - NP_001189405
RefSeq Peptide - NP_003332
swissprot - A0A024R2K3
swissprot - H7C061
swissprot - B7Z306
swissprot - P51965
swissprot - C9J2P0
Ensembl - ENSG00000170142
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpl15ENSDARG00000116649Danio rerio
 ube2e2ENSDARG00000034670Danio rerio
 UBE2E1ENSGALG00000011286Gallus gallus
 P52482ENSMUSG00000021774Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96LR5 / UBE2E2 / ubiquitin conjugating enzyme E2 E2ENSG0000018224785
Q969T4 / UBE2E3 / ubiquitin conjugating enzyme E2 E3ENSG0000017003583
P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2ENSG0000013150848
Q9Y2X8 / UBE2D4 / ubiquitin conjugating enzyme E2 D4 (putative)ENSG0000007896747
P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1ENSG0000007240146
P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3ENSG0000010933246
UBE2S / Q16763 / ubiquitin conjugating enzyme E2 SENSG0000010810626
P68036 / UBE2L3 / ubiquitin conjugating enzyme E2 L3ENSG0000018565126
UBE2L5 / ubiquitin conjugating enzyme E2 L5ENSG0000023644426
O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6ENSG0000015658725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0010390 histone monoubiquitination IDA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0032020 ISG15-protein conjugation IDA
 biological_processGO:0033523 histone H2B ubiquitination IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042296 ISG15 transferase activity IDA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IDA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / complex / reaction
 ENSG00000156587 O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6  / reaction
 ENSG00000166233 ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1  / reaction
 ENSG00000138646 HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5  / reaction






 

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