ENSDARG00000034670


Danio rerio

Features
Gene ID: ENSDARG00000034670
  
Biological name :ube2e2
  
Synonyms : ube2e2 / ubiquitin-conjugating enzyme E2E 2
  
Possible biological names infered from orthology : P51965 / P52482 / Q91W82 / Q96LR5 / UBE2E1 / ubiquitin conjugating enzyme E2 E1
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 50006145
Gene end: 50078469
  
Corresponding Affymetrix probe sets: Dr.4810.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000049374
Ensembl peptide - ENSDARP00000127974
NCBI entrez gene - 445100     See in Manteia.
swissprot - Q6DG68
swissprot - X1WCM9
ZFIN ID - ZDB-GENE-040801-237
Ensembl - ENSDARG00000034670
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UBE2E1ENSGALG00000011286Gallus gallus
 UBE2E2ENSGALG00000033593Gallus gallus
 P51965ENSG00000170142Homo sapiens
 Q96LR5ENSG00000182247Homo sapiens
 P52482ENSMUSG00000021774Mus musculus
 Q91W82ENSMUSG00000058317Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ube2e3 / ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) / P52483* / Q969T4* / ubiquitin conjugating enzyme E2 E3*ENSDARG0000001224487
rpl15 / ube2e1 / ubiquitin-conjugating enzyme E2E 1 / Q96LR5* / P51965* / UBE2E2* / ubiquitin conjugating enzyme E2 E2*ENSDARG0000011664982
ube2d2l / ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), likeENSDARG0000009974946
ube2d2 / ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) / P62838* / P62837* / Ube2d2a* / ubiquitin conjugating enzyme E2 D2* / ubiquitin-conjugating enzyme E2D 2A*ENSDARG0000004348446
ube2d3 / ubiquitin-conjugating enzyme E2D 3ENSDARG0000003847346
ube2d4 / ubiquitin-conjugating enzyme E2D 4 (putative) / Q9Y2X8*ENSDARG0000001505744
ube2d1b / ubiquitin-conjugating enzyme E2D 1b / UBE2D1* / P51668* / P61080* / ubiquitin conjugating enzyme E2 D1*ENSDARG0000003857644
ube2d1a / ubiquitin-conjugating enzyme E2D 1aENSDARG0000002910744
ube2l3a / ubiquitin-conjugating enzyme E2L 3a / UBE2L5* / P68036* / UBE2L3* / ubiquitin conjugating enzyme E2 L3* / ubiquitin conjugating enzyme E2 L5*ENSDARG0000011208725
ube2s / Q4V908 / ubiquitin-conjugating enzyme E2S / Q16763* / Q921J4*ENSDARG0000003177524
ube2l3b / ubiquitin-conjugating enzyme E2L 3b / UBE2L3* / P68036* / P68037* / UBE2L5* / ubiquitin conjugating enzyme E2 L3* / ubiquitin conjugating enzyme E2 L5*ENSDARG0000002714124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000023958 rnf181 / Q7ZW78 / ring finger protein 181 / Q9CY62* / Q9P0P0* / Mus musculus ring finger protein 181 (Rnf181), transcript variant 11, mRNA.*  / complex / reaction
 ENSDARG00000077130 bcl10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / reaction / complex






 

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