ENSMUSG00000021774


Mus musculus

Features
Gene ID: ENSMUSG00000021774
  
Biological name :Ube2e1
  
Synonyms : P52482 / Ube2e1 / ubiquitin-conjugating enzyme E2E 1
  
Possible biological names infered from orthology : P51965
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A2
Gene start: 18282722
Gene end: 18331859
  
Corresponding Affymetrix probe sets: 10417749 (MoGene1.0st)   1416943_at (Mouse Genome 430 2.0 Array)   1445933_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022296
Ensembl peptide - ENSMUSP00000153693
NCBI entrez gene - 22194     See in Manteia.
MGI - MGI:107411
RefSeq - XM_011244759
RefSeq - NM_009455
RefSeq Peptide - NP_033481
swissprot - P52482
swissprot - Q541Z5
swissprot - A0A286YE31
Ensembl - ENSMUSG00000021774
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpl15ENSDARG00000116649Danio rerio
 ube2e2ENSDARG00000034670Danio rerio
 UBE2E1ENSGALG00000011286Gallus gallus
 P51965ENSG00000170142Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91W82 / Ube2e2 / ubiquitin-conjugating enzyme E2E 2 / Q96LR5*ENSMUSG0000005831785
P52483 / Ube2e3 / ubiquitin-conjugating enzyme E2E 3 / Q969T4*ENSMUSG0000002701183
P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*ENSMUSG0000009189648
Ube2dnl2 / ubiquitin-conjugating enzyme E2D N-terminal like 2ENSMUSG0000004707948
Q6ZWY6 / Ube2d2b / ubiquitin-conjugating enzyme E2D 2BENSMUSG0000006344747
Ube2dnl1ENSMUSG0000005043546
P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*ENSMUSG0000007857846
P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*ENSMUSG0000001992746
P68037 / Ube2l3 / ubiquitin-conjugating enzyme E2L 3ENSMUSG0000003896527
Ube2s / Q921J4 / ubiquitin-conjugating enzyme E2S / Q16763*ENSMUSG0000006086026
Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*ENSMUSG0000002707822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0010390 histone monoubiquitination IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0032020 ISG15-protein conjugation IEA
 biological_processGO:0033523 histone H2B ubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042296 ISG15 transferase activity IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025234 Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*  / reaction
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / complex / reaction
 ENSMUSG00000055850 Q9CY62 / Rnf181 / Mus musculus ring finger protein 181 (Rnf181), transcript variant 11, mRNA. / Q9P0P0* / ring finger protein 181*  / reaction / complex
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / complex / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction






 

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