ENSMUSG00000078578


Mus musculus

Features
Gene ID: ENSMUSG00000078578
  
Biological name :Ube2d3
  
Synonyms : P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3
  
Possible biological names infered from orthology : P61077
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 135438149
Gene end: 135468198
  
Corresponding Affymetrix probe sets: 10469772 (MoGene1.0st)   10496295 (MoGene1.0st)   10605349 (MoGene1.0st)   1423112_at (Mouse Genome 430 2.0 Array)   1423113_a_at (Mouse Genome 430 2.0 Array)   1423114_at (Mouse Genome 430 2.0 Array)   1450858_a_at (Mouse Genome 430 2.0 Array)   1450859_s_at (Mouse Genome 430 2.0 Array)   1455479_a_at (Mouse Genome 430 2.0 Array)   1455480_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143065
Ensembl peptide - ENSMUSP00000143301
Ensembl peptide - ENSMUSP00000143758
Ensembl peptide - ENSMUSP00000143608
Ensembl peptide - ENSMUSP00000143606
Ensembl peptide - ENSMUSP00000101898
Ensembl peptide - ENSMUSP00000130096
Ensembl peptide - ENSMUSP00000142612
Ensembl peptide - ENSMUSP00000142763
Ensembl peptide - ENSMUSP00000142974
Ensembl peptide - ENSMUSP00000143013
NCBI entrez gene - 66105     See in Manteia.
MGI - MGI:1913355
RefSeq - NM_025356
RefSeq - XM_006501875
RefSeq - XM_006501874
RefSeq - XM_006501873
RefSeq - NM_001356594
RefSeq - NM_001356595
RefSeq - NM_001356596
RefSeq Peptide - NP_001343524
RefSeq Peptide - NP_001343523
RefSeq Peptide - NP_001343525
RefSeq Peptide - NP_001343526
RefSeq Peptide - NP_079632
swissprot - A0A0G2JGL0
swissprot - P61079
swissprot - Q05CK8
swissprot - Q4QQL2
swissprot - A0A0G2JGZ3
swissprot - A0A0G2JE32
swissprot - A0A0G2JF40
Ensembl - ENSMUSG00000078578
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P61077ENSG00000109332Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*ENSMUSG0000009189693
Q6ZWY6 / Ube2d2b / ubiquitin-conjugating enzyme E2D 2BENSMUSG0000006344786
P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*ENSMUSG0000001992784
Ube2dnl1ENSMUSG0000005043572
Ube2dnl2 / ubiquitin-conjugating enzyme E2D N-terminal like 2ENSMUSG0000004707972
P52483 / Ube2e3 / ubiquitin-conjugating enzyme E2E 3 / Q969T4*ENSMUSG0000002701161
Q91W82 / Ube2e2 / ubiquitin-conjugating enzyme E2E 2 / Q96LR5*ENSMUSG0000005831760
P52482 / Ube2e1 / ubiquitin-conjugating enzyme E2E 1 / P51965*ENSMUSG0000002177460
P68037 / Ube2l3 / ubiquitin-conjugating enzyme E2L 3ENSMUSG0000003896537
Ube2s / Q921J4 / ubiquitin-conjugating enzyme E2S / Q16763*ENSMUSG0000006086035
Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*ENSMUSG0000002707829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0051865 protein autoubiquitination ISO
 biological_processGO:0070936 protein K48-linked ubiquitination ISS
 biological_processGO:0070979 protein K11-linked ubiquitination ISO
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity ISO


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018733 Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*  / complex / reaction
 ENSMUSG00000055850 Q9CY62 / Rnf181 / Mus musculus ring finger protein 181 (Rnf181), transcript variant 11, mRNA. / Q9P0P0* / ring finger protein 181*  / reaction / complex
 ENSMUSG00000028975 Pex14 / Q9R0A0 / Peroxisomal membrane protein PEX14 / O75381* / peroxisomal biogenesis factor 14*  / complex / reaction
 ENSMUSG00000040374 Pex2 / peroxisomal biogenesis factor 2 / P28328*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / reaction
 ENSMUSG00000025239 Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*  / reaction
 ENSMUSG00000031987 Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*  / reaction
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / complex / reaction
 ENSMUSG00000029047 Pex10 / B1AUE5 / Peroxisome biosis factor 10 / O60683* / peroxisomal biogenesis factor 10*  / reaction / complex
 ENSMUSG00000024140 Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*  / reaction
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / complex / reaction
 ENSMUSG00000004328 Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*  / reaction
 ENSMUSG00000024231 Cul2 / Q9D4H8 / Cullin-2 / Q13617*  / reaction
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / reaction
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / reaction
 ENSMUSG00000035105 Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex
 ENSMUSG00000020003 Pex7 / P97865 / Peroxisomal targeting signal 2 receptor / O00628* / peroxisomal biogenesis factor 7*  / complex / reaction
 ENSMUSG00000020283 Pex13 / Q9D0K1 / Peroxisomal membrane protein PEX13 / Q92968* / peroxisomal biogenesis factor 13*  / reaction / complex
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / reaction






 

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