ENSMUSG00000040374


Mus musculus

Features
Gene ID: ENSMUSG00000040374
  
Biological name :Pex2
  
Synonyms : peroxisomal biogenesis factor 2 / Pex2
  
Possible biological names infered from orthology : P28328
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A1
Gene start: 5560188
Gene end: 5576239
  
Corresponding Affymetrix probe sets: 10497173 (MoGene1.0st)   1420711_a_at (Mouse Genome 430 2.0 Array)   1437443_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059415
Ensembl peptide - ENSMUSP00000071255
Ensembl peptide - ENSMUSP00000126445
Ensembl peptide - ENSMUSP00000129311
Ensembl peptide - ENSMUSP00000141927
Ensembl peptide - ENSMUSP00000141945
NCBI entrez gene - 19302     See in Manteia.
MGI - MGI:107486
RefSeq - XM_017319505
RefSeq - NM_001163301
RefSeq - NM_001163302
RefSeq - NM_001163305
RefSeq - NM_001163306
RefSeq - NM_001267714
RefSeq - NM_001267715
RefSeq - NM_008994
RefSeq - XM_006530058
RefSeq - XM_006530059
RefSeq - XM_011248140
RefSeq Peptide - NP_001156778
RefSeq Peptide - NP_001254644
RefSeq Peptide - NP_033020
RefSeq Peptide - NP_001254643
RefSeq Peptide - NP_001156773
RefSeq Peptide - NP_001156774
RefSeq Peptide - NP_001156777
swissprot - Q91YZ5
Ensembl - ENSMUSG00000040374
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pex2ENSDARG00000062421Danio rerio
 PEX2ENSGALG00000035752Gallus gallus
 PEX2ENSG00000164751Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR006845  Pex, N-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0007031 peroxisome organization IEA
 biological_processGO:0016558 protein import into peroxisome matrix IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005779 integral component of peroxisomal membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016593 Cdc73/Paf1 complex IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
E3 ubiquitin ligases ubiquitinate target proteins
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000077 abnormal interparietal bone morphology "malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]
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Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000436 abnormal head movements "anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000610 cholestasis "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001553 abnormal circulating free fatty acids level "anomalous blood concentrations of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0003420 delayed intramembranous bone ossification "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Pex2tm1Plf/Pex2tm1Plf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002763 Pex6 / Q99LC9 / Peroxisome assembly factor 2 / Q13608* / peroxisomal biogenesis factor 6*  / reaction / complex
 ENSMUSG00000005907 Pex1 / Q5BL07 / Peroxisome biosis factor 1 / O43933* / peroxisomal biogenesis factor 1*  / complex / reaction
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction / complex
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / complex / reaction
 ENSMUSG00000030629 Q9DCH6 / Zfand6 / zinc finger, AN1-type domain 6 / Q6FIF0* / zinc finger AN1-type containing 6*  / complex / reaction
 ENSMUSG00000036138 Acaa1a / Q921H8 / acetyl-Coenzyme A acyltransferase 1A / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*  / complex
 ENSMUSG00000010651 Acaa1b / Q8VCH0 / acetyl-Coenzyme A acyltransferase 1B / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*  / complex
 ENSMUSG00000026664 Phyh / O35386 / phytanoyl-CoA hydroxylase / O14832* / phytanoyl-CoA 2-hydroxylase*  / complex
 ENSMUSG00000018733 Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*  / complex
 ENSMUSG00000028975 Pex14 / Q9R0A0 / Peroxisomal membrane protein PEX14 / O75381* / peroxisomal biogenesis factor 14*  / complex
 ENSMUSG00000029047 Pex10 / B1AUE5 / Peroxisome biosis factor 10 / O60683* / peroxisomal biogenesis factor 10*  / complex
 ENSMUSG00000067825 Pex26 / Q8BGI5 / Peroxisome assembly protein 26 / Q7Z412* / peroxisomal biogenesis factor 26*  / reaction / complex
 ENSMUSG00000020283 Pex13 / Q9D0K1 / Peroxisomal membrane protein PEX13 / Q92968* / peroxisomal biogenesis factor 13*  / complex
 ENSMUSG00000020003 Pex7 / P97865 / Peroxisomal targeting signal 2 receptor / O00628* / peroxisomal biogenesis factor 7*  / complex
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / complex / reaction
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / reaction / complex






 

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