ENSMUSG00000005907


Mus musculus

Features
Gene ID: ENSMUSG00000005907
  
Biological name :Pex1
  
Synonyms : Peroxisome biosis factor 1 / Pex1 / Q5BL07
  
Possible biological names infered from orthology : O43933 / peroxisomal biogenesis factor 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 3596066
Gene end: 3637232
  
Corresponding Affymetrix probe sets: 10519354 (MoGene1.0st)   1428716_at (Mouse Genome 430 2.0 Array)   1440267_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121813
Ensembl peptide - ENSMUSP00000116645
Ensembl peptide - ENSMUSP00000142620
Ensembl peptide - ENSMUSP00000006061
Ensembl peptide - ENSMUSP00000113304
Ensembl peptide - ENSMUSP00000116474
NCBI entrez gene - 71382     See in Manteia.
MGI - MGI:1918632
RefSeq - XM_017321101
RefSeq - NM_001293806
RefSeq - NM_027777
RefSeq - XM_006503607
RefSeq - XM_017321100
RefSeq Peptide - NP_001280735
RefSeq Peptide - NP_082053
swissprot - F7CF88
swissprot - D3Z5A7
swissprot - Q5BL07
swissprot - F6RUH9
swissprot - A0A0G2JE39
Ensembl - ENSMUSG00000005907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pex1ENSDARG00000098904Danio rerio
 PEX1ENSGALG00000009410Gallus gallus
 PEX1ENSG00000127980Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR009010  Aspartate decarboxylase-like domain superfamily
 IPR015342  Peroxisome biogenesis factor 1, N-terminal, psi beta-barrel fold
 IPR015343  Peroxisome biogenesis factor 1, N-terminal, alpha/beta
 IPR025653  Peroxisome biogenesis factor 1
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029067  CDC48 domain 2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006625 protein targeting to peroxisome IEA
 biological_processGO:0007031 peroxisome organization ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016558 protein import into peroxisome matrix IEA
 biological_processGO:0060152 microtubule-based peroxisome localization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0042623 ATPase activity, coupled IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000610 cholestasis "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003255 bile duct proliferation "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005284 increased saturated fatty acid level "greater than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain contains only single carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0006084 abnormal circulating phospholipid level "anomalous concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002763 Pex6 / Q99LC9 / Peroxisome assembly factor 2 / Q13608* / peroxisomal biogenesis factor 6*  / complex
 ENSMUSG00000005907 Pex1 / Q5BL07 / Peroxisome biosis factor 1 / O43933* / peroxisomal biogenesis factor 1*  / complex
 ENSMUSG00000030629 Q9DCH6 / Zfand6 / zinc finger, AN1-type domain 6 / Q6FIF0* / zinc finger AN1-type containing 6*  / complex / reaction
 ENSMUSG00000020003 Pex7 / P97865 / Peroxisomal targeting signal 2 receptor / O00628* / peroxisomal biogenesis factor 7*  / reaction / complex
 ENSMUSG00000040374 Pex2 / peroxisomal biogenesis factor 2 / P28328*  / reaction / complex
 ENSMUSG00000028975 Pex14 / Q9R0A0 / Peroxisomal membrane protein PEX14 / O75381* / peroxisomal biogenesis factor 14*  / complex / reaction
 ENSMUSG00000018733 Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*  / complex / reaction
 ENSMUSG00000067825 Pex26 / Q8BGI5 / Peroxisome assembly protein 26 / Q7Z412* / peroxisomal biogenesis factor 26*  / complex
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / complex / reaction
 ENSMUSG00000029047 Pex10 / B1AUE5 / Peroxisome biosis factor 10 / O60683* / peroxisomal biogenesis factor 10*  / reaction / complex
 ENSMUSG00000020283 Pex13 / Q9D0K1 / Peroxisomal membrane protein PEX13 / Q92968* / peroxisomal biogenesis factor 13*  / reaction / complex






 

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