ENSMUSG00000029047


Mus musculus

Features
Gene ID: ENSMUSG00000029047
  
Biological name :Pex10
  
Synonyms : B1AUE5 / Peroxisome biosis factor 10 / Pex10
  
Possible biological names infered from orthology : O60683 / peroxisomal biogenesis factor 10
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 155067016
Gene end: 155072433
  
Corresponding Affymetrix probe sets: 10510982 (MoGene1.0st)   1456646_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099469
NCBI entrez gene - 668173     See in Manteia.
MGI - MGI:2684988
RefSeq - NM_001042407
RefSeq Peptide - NP_001035866
swissprot - B1AUE5
Ensembl - ENSMUSG00000029047
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pex10ENSDARG00000041511Danio rerio
 PEX10ENSGALG00000001223Gallus gallus
 PEX10ENSG00000157911Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR006845  Pex, N-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR025654  Peroxisome biogenesis factor 10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007031 peroxisome organization ISO
 biological_processGO:0016558 protein import into peroxisome matrix ISO
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005778 peroxisomal membrane IBA
 cellular_componentGO:0005779 integral component of peroxisomal membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
E3 ubiquitin ligases ubiquitinate target proteins
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0000756 forelimb paralysis "loss of power of voluntary movement in muscles of the forlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Pex10m1Nisw/Pex10+
Genetic Background: 129S1.B6-Pex10m1Nisw

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0012216 decreased plasmalogen level "reduction in the amount of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone" [PMID:19519379, PMID:22627108]
Show

Allelic Composition: Ptpn11tm1.1Ics/Ptpn11+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Pex10m1Nisw/Pex10+
Genetic Background: 129S1.B6-Pex10m1Nisw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002763 Pex6 / Q99LC9 / Peroxisome assembly factor 2 / Q13608* / peroxisomal biogenesis factor 6*  / complex / reaction
 ENSMUSG00000005907 Pex1 / Q5BL07 / Peroxisome biosis factor 1 / O43933* / peroxisomal biogenesis factor 1*  / complex / reaction
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction / complex
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / reaction / complex
 ENSMUSG00000040374 Pex2 / peroxisomal biogenesis factor 2 / P28328*  / complex
 ENSMUSG00000030629 Q9DCH6 / Zfand6 / zinc finger, AN1-type domain 6 / Q6FIF0* / zinc finger AN1-type containing 6*  / reaction / complex
 ENSMUSG00000067825 Pex26 / Q8BGI5 / Peroxisome assembly protein 26 / Q7Z412* / peroxisomal biogenesis factor 26*  / reaction / complex
 ENSMUSG00000010651 Acaa1b / Q8VCH0 / acetyl-Coenzyme A acyltransferase 1B / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*  / complex
 ENSMUSG00000026664 Phyh / O35386 / phytanoyl-CoA hydroxylase / O14832* / phytanoyl-CoA 2-hydroxylase*  / complex
 ENSMUSG00000018733 Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*  / complex
 ENSMUSG00000028975 Pex14 / Q9R0A0 / Peroxisomal membrane protein PEX14 / O75381* / peroxisomal biogenesis factor 14*  / complex
 ENSMUSG00000036138 Acaa1a / Q921H8 / acetyl-Coenzyme A acyltransferase 1A / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*  / complex
 ENSMUSG00000020283 Pex13 / Q9D0K1 / Peroxisomal membrane protein PEX13 / Q92968* / peroxisomal biogenesis factor 13*  / complex
 ENSMUSG00000020003 Pex7 / P97865 / Peroxisomal targeting signal 2 receptor / O00628* / peroxisomal biogenesis factor 7*  / complex
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / complex / reaction
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / reaction / complex






 

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