ENSMUSG00000020283


Mus musculus

Features
Gene ID: ENSMUSG00000020283
  
Biological name :Pex13
  
Synonyms : Peroxisomal membrane protein PEX13 / Pex13 / Q9D0K1
  
Possible biological names infered from orthology : peroxisomal biogenesis factor 13 / Q92968
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A3.2
Gene start: 23646479
Gene end: 23665959
  
Corresponding Affymetrix probe sets: 10384717 (MoGene1.0st)   1422471_at (Mouse Genome 430 2.0 Array)   1422472_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115020
Ensembl peptide - ENSMUSP00000020523
NCBI entrez gene - 72129     See in Manteia.
MGI - MGI:1919379
RefSeq - NM_023651
RefSeq Peptide - NP_076140
swissprot - D6RH41
swissprot - Q9D0K1
Ensembl - ENSMUSG00000020283
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pex13ENSDARG00000071037Danio rerio
 PEX13ENSGALG00000007832Gallus gallus
 PEX13ENSG00000162928Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR007223  Peroxin 13, N-terminal
 IPR035463  Peroxin 13
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001561 fatty acid alpha-oxidation IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001967 suckling behavior IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016560 protein import into peroxisome matrix, docking ISO
 biological_processGO:0021795 cerebral cortex cell migration IMP
 biological_processGO:0060152 microtubule-based peroxisome localization IMP
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005778 peroxisomal membrane ISO
 cellular_componentGO:0005779 integral component of peroxisomal membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000268 peroxisome targeting sequence binding TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
E3 ubiquitin ligases ubiquitinate target proteins
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0008059 abnormal podocyte foot process morphology "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0008291 abnormal adrenocortical cell morphology "any structural anomaly of the steroid hormone-producing cells of the cortex of the adrenal gland" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0008579 abnormal Purkinje cell differentiation "atypical production of or inability to produce the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0009267 abnormal cerebellum fissure morphology "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0012217 increased plasmalogen level "greater amount of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone" [PMID:19519379, PMID:22627108]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

 MP:0012218 decreased brain plasmalogen level "reduction in the amount in the brain of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone" [PMID:19519379, PMID:22627108]
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Allelic Composition: Pex13tm1Crne/Pex13tm1.1Crne,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002763 Pex6 / Q99LC9 / Peroxisome assembly factor 2 / Q13608* / peroxisomal biogenesis factor 6*  / reaction / complex
 ENSMUSG00000005907 Pex1 / Q5BL07 / Peroxisome biosis factor 1 / O43933* / peroxisomal biogenesis factor 1*  / reaction / complex
 ENSMUSG00000010651 Acaa1b / Q8VCH0 / acetyl-Coenzyme A acyltransferase 1B / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*  / complex
 ENSMUSG00000036138 Acaa1a / Q921H8 / acetyl-Coenzyme A acyltransferase 1A / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*  / complex
 ENSMUSG00000026664 Phyh / O35386 / phytanoyl-CoA hydroxylase / O14832* / phytanoyl-CoA 2-hydroxylase*  / complex
 ENSMUSG00000030629 Q9DCH6 / Zfand6 / zinc finger, AN1-type domain 6 / Q6FIF0* / zinc finger AN1-type containing 6*  / complex / reaction
 ENSMUSG00000067825 Pex26 / Q8BGI5 / Peroxisome assembly protein 26 / Q7Z412* / peroxisomal biogenesis factor 26*  / complex / reaction
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / complex / reaction
 ENSMUSG00000020003 Pex7 / P97865 / Peroxisomal targeting signal 2 receptor / O00628* / peroxisomal biogenesis factor 7*  / complex
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction / complex
 ENSMUSG00000018733 Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*  / complex
 ENSMUSG00000040374 Pex2 / peroxisomal biogenesis factor 2 / P28328*  / complex
 ENSMUSG00000029047 Pex10 / B1AUE5 / Peroxisome biosis factor 10 / O60683* / peroxisomal biogenesis factor 10*  / complex
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / reaction / complex
 ENSMUSG00000028975 Pex14 / Q9R0A0 / Peroxisomal membrane protein PEX14 / O75381* / peroxisomal biogenesis factor 14*  / complex
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / reaction / complex






 

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