Manteia

ENSMUSG00000028975

Mus musculus

Features

Gene ID:	ENSMUSG00000028975

Biological name :	Pex14

Synonyms :	Peroxisomal membrane protein PEX14 / Pex14 / Q9R0A0

Possible biological names infered from orthology :	O75381 / peroxisomal biogenesis factor 14

Species:	Mus musculus

Chr. number:	4
Strand:	-1
Band:	E2
Gene start:	148960535
Gene end:	149099876

Corresponding Affymetrix probe sets:	10518546 (MoGene1.0st) 1419053_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000116791 Ensembl peptide - ENSMUSP00000099506 NCBI entrez gene - 56273 See in Manteia. MGI - MGI:1927868 RefSeq - NM_019781 RefSeq Peptide - NP_062755 swissprot - D6RH82 swissprot - Q9R0A0 Ensembl - ENSMUSG00000028975

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pex14	ENSDARG00000028322	Danio rerio
PEX14	ENSGALG00000002836	Gallus gallus
PEX14	ENSG00000142655	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR006785	Peroxisome membrane anchor protein Pex14p, N-terminal
IPR025655	Peroxisomal membrane protein 14

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007031	peroxisome organization	IEA
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0016558	protein import into peroxisome matrix	IEA
biological_process	GO:0016560	protein import into peroxisome matrix, docking	IEA
biological_process	GO:0016561	protein import into peroxisome matrix, translocation	IEA
biological_process	GO:0032091	negative regulation of protein binding	IEA
biological_process	GO:0034453	microtubule anchoring	IEA
biological_process	GO:0036250	peroxisome transport along microtubule	IEA
biological_process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IEA
biological_process	GO:0044721	protein import into peroxisome matrix, substrate release	IEA
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IEA
biological_process	GO:0051260	protein homooligomerization	IEA
biological_process	GO:0065003	protein-containing complex assembly	IEA
biological_process	GO:1901094	negative regulation of protein homotetramerization	IEA
cellular_component	GO:0001650	fibrillar center	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005777	peroxisome	ISO
cellular_component	GO:0005778	peroxisomal membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
cellular_component	GO:1990429	peroxisomal importomer complex	IBA
molecular_function	GO:0003714	transcription corepressor activity	IEA
molecular_function	GO:0005102	signaling receptor binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0008017	microtubule binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0047485	protein N-terminus binding	IEA
molecular_function	GO:0048487	beta-tubulin binding	IEA

Pathways (from Reactome)

Pathway description

E3 ubiquitin ligases ubiquitinate target proteins

Peroxisomal protein import

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Hprt^b-m3/Y,Impdh2^tm1Bmi/Impdh2⁺ Genetic Background: involves: 129P2/OlaHsd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000002763	Pex6 / Q99LC9 / Peroxisome assembly factor 2 / Q13608* / peroxisomal biogenesis factor 6*	/ complex / reaction
ENSMUSG00000005907	Pex1 / Q5BL07 / Peroxisome biosis factor 1 / O43933* / peroxisomal biogenesis factor 1*	/ complex / reaction
ENSMUSG00000019927	P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*	/ reaction / complex
ENSMUSG00000020003	Pex7 / P97865 / Peroxisomal targeting signal 2 receptor / O00628* / peroxisomal biogenesis factor 7*	/ complex
ENSMUSG00000018733	Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*	/ complex
ENSMUSG00000005069	Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*	/ complex / reaction
ENSMUSG00000040374	Pex2 / peroxisomal biogenesis factor 2 / P28328*	/ complex
ENSMUSG00000030629	Q9DCH6 / Zfand6 / zinc finger, AN1-type domain 6 / Q6FIF0* / zinc finger AN1-type containing 6*	/ complex / reaction
ENSMUSG00000067825	Pex26 / Q8BGI5 / Peroxisome assembly protein 26 / Q7Z412* / peroxisomal biogenesis factor 26*	/ reaction / complex
ENSMUSG00000029047	Pex10 / B1AUE5 / Peroxisome biosis factor 10 / O60683* / peroxisomal biogenesis factor 10*	/ complex
ENSMUSG00000078578	P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*	/ reaction / complex
ENSMUSG00000020283	Pex13 / Q9D0K1 / Peroxisomal membrane protein PEX13 / Q92968* / peroxisomal biogenesis factor 13*	/ complex
ENSMUSG00000036138	Acaa1a / Q921H8 / acetyl-Coenzyme A acyltransferase 1A / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*	/ complex
ENSMUSG00000026664	Phyh / O35386 / phytanoyl-CoA hydroxylase / O14832* / phytanoyl-CoA 2-hydroxylase*	/ complex
ENSMUSG00000010651	Acaa1b / Q8VCH0 / acetyl-Coenzyme A acyltransferase 1B / ACAA1* / P09110* / acetyl-CoA acyltransferase 1*	/ complex
ENSMUSG00000091896	P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr