ENSMUSG00000026664


Mus musculus

Features
Gene ID: ENSMUSG00000026664
  
Biological name :Phyh
  
Synonyms : O35386 / Phyh / phytanoyl-CoA hydroxylase
  
Possible biological names infered from orthology : O14832 / phytanoyl-CoA 2-hydroxylase
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A1
Gene start: 4919019
Gene end: 4938730
  
Corresponding Affymetrix probe sets: 10469046 (MoGene1.0st)   1460194_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027975
NCBI entrez gene - 16922     See in Manteia.
MGI - MGI:891978
RefSeq - NM_010726
RefSeq Peptide - NP_034856
swissprot - O35386
swissprot - Q3TPC7
Ensembl - ENSMUSG00000026664
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phyhENSDARG00000086740Danio rerio
 PHYHENSGALG00000035636Gallus gallus
 PHYHENSG00000107537Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008775  Phytanoyl-CoA dioxygenase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001561 fatty acid alpha-oxidation IEA
 biological_processGO:0006103 2-oxoglutarate metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006720 isoprenoid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097089 methyl-branched fatty acid metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005777 peroxisome TAS
 molecular_functionGO:0003824 catalytic activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008198 ferrous iron binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031406 carboxylic acid binding IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048037 cofactor binding IEA
 molecular_functionGO:0048244 phytanoyl-CoA dioxygenase activity ISO
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Alpha-oxidation of phytanate
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008570 lipidosis "abnormal fat metabolism with increased accumulation of specific lipids in tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020087 Q9DBA6 / Tysnd1 / trypsin domain containing 1 / Q2T9J0*  / reaction
 ENSMUSG00000020283 Pex13 / Q9D0K1 / Peroxisomal membrane protein PEX13 / Q92968* / peroxisomal biogenesis factor 13*  / complex
 ENSMUSG00000018733 Pex12 / Q8VC48 / Peroxisome assembly protein 12 / O00623* / peroxisomal biogenesis factor 12*  / complex
 ENSMUSG00000020003 Pex7 / P97865 / Peroxisomal targeting signal 2 receptor / O00628* / peroxisomal biogenesis factor 7*  / complex / reaction
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / complex
 ENSMUSG00000040374 Pex2 / peroxisomal biogenesis factor 2 / P28328*  / complex
 ENSMUSG00000029047 Pex10 / B1AUE5 / Peroxisome biosis factor 10 / O60683* / peroxisomal biogenesis factor 10*  / complex
 ENSMUSG00000028975 Pex14 / Q9R0A0 / Peroxisomal membrane protein PEX14 / O75381* / peroxisomal biogenesis factor 14*  / complex






 

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