ENSMUSG00000031987


Mus musculus

Features
Gene ID: ENSMUSG00000031987
  
Biological name :Egln1
  
Synonyms : Egln1 / Egl nine homolog 1 / Q91YE3
  
Possible biological names infered from orthology : egl-9 family hypoxia inducible factor 1 / Q9GZT9
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E2
Gene start: 124908587
Gene end: 124949324
  
Corresponding Affymetrix probe sets: 10582712 (MoGene1.0st)   1423785_at (Mouse Genome 430 2.0 Array)   1451110_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034469
NCBI entrez gene - 112405     See in Manteia.
MGI - MGI:1932286
RefSeq - NM_053207
RefSeq - XM_006530578
RefSeq Peptide - NP_444437
swissprot - Q91YE3
Ensembl - ENSMUSG00000031987
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egln1aENSDARG00000038996Danio rerio
 egln1bENSDARG00000105156Danio rerio
 egln1bENSDARG00000004632Danio rerio
 EGLN1ENSGALG00000041422Gallus gallus
 EGLN1ENSG00000135766Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egln2 / Q91YE2 / Egl nine homolog 2 / Q96KS0* / egl-9 family hypoxia inducible factor 2*ENSMUSG0000005870942
Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*ENSMUSG0000003510537


Protein motifs (from Interpro)
Interpro ID Name
 IPR002893  Zinc finger, MYND-type
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
 biological_processGO:0032364 oxygen homeostasis IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045765 regulation of angiogenesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060347 heart trabecula formation IMP
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060711 labyrinthine layer development IMP
 biological_processGO:0071731 response to nitric oxide IEA
 biological_processGO:1901214 regulation of neuron death IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0031545 peptidyl-proline 4-dioxygenase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

Allelic Composition: Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Axd/Axd+,Grhl3ct/Grhl3+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6 * GFF

 MP:0000440 domed skull 
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Epas1tm1Mcs/Epas1tm1Mcs,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Apaf1fog/Apaf1tm1Her
Genetic Background: involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0001598 abnormal blood viscosity "anomaly in the resistance to flow of the blood through the vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001711 abnormal placenta 
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Epas1tm1Mcs/Epas1tm1Mcs,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1fog/Apaf1tm1Her
Genetic Background: involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Egln1tm2.1Fsl Tg(Cdh5-cre)7Mlia

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Epas1tm1Mcs/Epas1tm1Mcs,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Epas1tm1Mcs

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0002450 abnormal lymph organ development "anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Egln2tm2Fong/Egln2tm2Fong,Egln3tm2Fong/Egln3tm2Fong,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * CD-1

Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Egln1tm2.1Fsl/Egln1+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Egln1tm2.1Fsl Commd10Tg(Vav1-icre)A2Kio

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

Allelic Composition: Egln1tm2.2Fsl/Egln1+
Genetic Background: B6.Cg-Egln1tm2.2Fsl

Allelic Composition: Egln1tm1.1Fsl/Egln1+,Hif1atm3.1Rsjo/Hif1a+
Genetic Background: B6.Cg-Egln1tm1.1Fsl Hif1atm3.1Rsjo

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg,P4htmtm1Jomy/P4htmtm1Jomy
Genetic Background: Not Specified

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Egln1tm2.1Fsl Tg(Cdh5-cre)7Mlia

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Egln1tm2.1Fsl/Egln1+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Egln1tm2.1Fsl Commd10Tg(Vav1-icre)A2Kio

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl

Allelic Composition: Egln1tm2.2Fsl/Egln1+
Genetic Background: B6.Cg-Egln1tm2.2Fsl

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Egln3tm2Fong/Egln3tm2Fong,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Epas1tm1Mcs/Epas1tm1Mcs,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Axd/Axd+,Grhl3ct/Grhl3+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6 * GFF

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Egln1tm2.1Fsl Commd10Tg(Vav1-icre)A2Kio

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Axd/Axd+,Grhl3ct/Grhl3+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6 * GFF

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0004120 cardiac ischemia "inadequate blood blow to the heart; may cause infarction and is usually caused by coronary artery disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

Allelic Composition: Egln1tm2.2Fsl/Egln1+
Genetic Background: B6.Cg-Egln1tm2.2Fsl

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Egln1tm2.1Fsl Commd10Tg(Vav1-icre)A2Kio

Allelic Composition: Egln1tm2.2Fsl/Egln1+
Genetic Background: B6.Cg-Egln1tm2.2Fsl

 MP:0005575 increased pulmonary ventilation "greater than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
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Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

Allelic Composition: Egln1tm2.2Fsl/Egln1+
Genetic Background: B6.Cg-Egln1tm2.2Fsl

 MP:0005585 increased tidal volume "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg,P4htmtm1Jomy/P4htmtm1Jomy
Genetic Background: Not Specified

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009820 abnormal liver vasculature morphology "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0010127 hypervolemia "an abnormally increased amount of space occupied by blood in the vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axd/Axd+,Grhl3ct/Grhl3+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6 * GFF

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pitx1tm1Rsd/Pitx1tm1Rsd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Egln1tm1.1Fsl/Egln1tm1.1Fsl
Genetic Background: C57BL/6-Egln1tm1.1Fsl

Allelic Composition: Egln1tm2.2Fsl/Egln1tm2.2Fsl
Genetic Background: B6.Cg-Egln1tm2.2Fsl

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Myl2tm1(cre)Krc/Myl2+
Genetic Background: B6.Cg-Myl2tm1(cre)Krc Egln1tm1.1Brei

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011286 decreased circulating erythropoietin level "reduced blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg,P4htmtm1Jomy/P4htmtm1Jomy
Genetic Background: Not Specified

 MP:0011287 increased erythropoietin level "greater fluid or tissue concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl

Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0012397 abnormal nucleated erythrocyte cell number "abnormal numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MPD:Molly]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: C57BL/6

 MP:0020327 abnormal capillary branching pattern "any changes in the placement, morphology or number of divisions of the capillaries" [ORCID: orcid.org/0000-0003-4606-0597, PMID:14713950]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction
 ENSMUSG00000024140 Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*  / complex / reaction
 ENSMUSG00000024231 Cul2 / Q9D4H8 / Cullin-2 / Q13617*  / complex
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000025239 Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*  / complex
 ENSMUSG00000004328 Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*  / complex / reaction
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / complex
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / complex
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / reaction
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / complex
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / reaction






 

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