ENSMUSG00000035105


Mus musculus

Features
Gene ID: ENSMUSG00000035105
  
Biological name :Egln3
  
Synonyms : egl-9 family hypoxia inducible factor 3 / Egln3
  
Possible biological names infered from orthology : Q9H6Z9
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C1
Gene start: 54178981
Gene end: 54203860
  
Corresponding Affymetrix probe sets: 10400304 (MoGene1.0st)   1418648_at (Mouse Genome 430 2.0 Array)   1418649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041874
NCBI entrez gene - 112407     See in Manteia.
MGI - MGI:1932288
RefSeq - NM_028133
RefSeq Peptide - NP_082409
swissprot - A0A0R4J0H9
Ensembl - ENSMUSG00000035105
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egln3ENSDARG00000032553Danio rerio
 EGLN3ENSGALG00000010001Gallus gallus
 EGLN3ENSG00000129521Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*ENSMUSG0000003198761
Egln2 / Q91YE2 / Egl nine homolog 2 / Q96KS0* / egl-9 family hypoxia inducible factor 2*ENSMUSG0000005870954


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0018126 protein hydroxylation IEA
 biological_processGO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0031545 peptidyl-proline 4-dioxygenase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Egln3tm1Pjr/Egln3tm1Pjr,Epas1tm1Pec/Epas1+
Genetic Background: involves: 129S/SvEv * Swiss

 MP:0001013 enlarged superior cervical ganglion "increased size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:17131]
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Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001317 abnormal pupil morphology "structural anomaly of the central circular aperture of the iris through which light rays enter the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: HrM3Btlr/HrM3Btlr
Genetic Background: C57BL/6J-HrM3Btlr

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Egln2tm2Fong/Egln2tm2Fong,Egln3tm2Fong/Egln3tm2Fong,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * CD-1

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Egln3tm2Fong/Egln3tm2Fong,Tg(CD68-icre)1Bwlx/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0003437 abnormal carotid body morphology "any malformation in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, monikat:Monika Tomczuk, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Egln3tm1Pjr/Egln3tm1Pjr,Hif1atm1Pec/Hif1a+
Genetic Background: involves: 129S/SvEv * Swiss

Allelic Composition: Egln3tm1Pjr/Egln3tm1Pjr,Epas1tm1Pec/Epas1+
Genetic Background: involves: 129S/SvEv * Swiss

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005661 decreased circulating adrenaline level "less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0005664 decreased circulating noradrenaline level "less than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0008289 abnormal adrenal medulla morphology "any structural anomaly of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine" [MESH:A06.407.071.265, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0008504 abnormal adrenal chromaffin cell morphology "any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlr+,Tg(H2-K-AKR1B1)1Tj/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Egln3tm1Vlcg/Egln3tm1Vlcg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019927 P61080 / Ube2d1 / ubiquitin-conjugating enzyme E2D 1 / P51668*  / reaction
 ENSMUSG00000024140 Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*  / complex / reaction
 ENSMUSG00000024231 Cul2 / Q9D4H8 / Cullin-2 / Q13617*  / complex
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000025239 Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*  / complex
 ENSMUSG00000004328 Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*  / reaction / complex
 ENSMUSG00000033933 Vhl / P40338 / von Hippel-Lindau tumor suppressor / VHLL* / Q6RSH7* / P40337* / VHL like*  / complex
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / complex
 ENSMUSG00000078578 P61079 / Ube2d3 / ubiquitin-conjugating enzyme E2D 3 / P61077*  / reaction
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / complex
 ENSMUSG00000091896 P62838 / Ube2d2a / ubiquitin-conjugating enzyme E2D 2A / UBE2D2* / P62837* / ubiquitin conjugating enzyme E2 D2*  / reaction






 

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