ENSG00000129521


Homo sapiens

Features
Gene ID: ENSG00000129521
  
Biological name :EGLN3
  
Synonyms : egl-9 family hypoxia inducible factor 3 / EGLN3 / Q9H6Z9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q13.1
Gene start: 33924231
Gene end: 34462774
  
Corresponding Affymetrix probe sets: 219232_s_at (Human Genome U133 Plus 2.0 Array)   222847_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000446572
Ensembl peptide - ENSP00000250457
Ensembl peptide - ENSP00000447470
Ensembl peptide - ENSP00000451316
NCBI entrez gene - 112399     See in Manteia.
OMIM - 606426
RefSeq - NM_001308103
RefSeq - NM_022073
RefSeq Peptide - NP_001295032
RefSeq Peptide - NP_071356
swissprot - Q9H6Z9
swissprot - F8VR39
swissprot - F8W1G2
swissprot - G3V3M1
Ensembl - ENSG00000129521
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egln3ENSDARG00000032553Danio rerio
 EGLN3ENSGALG00000010001Gallus gallus
 Egln3ENSMUSG00000035105Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EGLN1 / Q9GZT9 / egl-9 family hypoxia inducible factor 1ENSG0000013576661
EGLN2 / Q96KS0 / egl-9 family hypoxia inducible factor 2ENSG0000026985853
AC008537.1ENSG000002687978


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEP
 biological_processGO:0006915 apoptotic process IEP
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0018126 protein hydroxylation IDA
 biological_processGO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline IDA
 biological_processGO:0042127 regulation of cell proliferation IEP
 biological_processGO:0043523 regulation of neuron apoptotic process ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0031545 peptidyl-proline 4-dioxygenase activity EXP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000131508 P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2  / reaction
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / reaction / complex
 ENSG00000124440 HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit  / complex / reaction
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / reaction / complex
 ENSG00000144791 LIMD1 / Q9UGP4 / LIM domains containing 1  / complex
 ENSG00000103363 ELOB / Q15370 / elongin B  / complex
 ENSG00000134086 VHL / P40337 / von Hippel-Lindau tumor suppressor  / complex
 ENSG00000154582 ELOC / Q15369 / elongin C  / complex
 ENSG00000109332 P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3  / reaction
 ENSG00000108094 CUL2 / Q13617 / cullin 2  / complex
 ENSG00000072401 P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1  / reaction






 

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