ENSG00000144791


Homo sapiens

Features
Gene ID: ENSG00000144791
  
Biological name :LIMD1
  
Synonyms : LIMD1 / LIM domains containing 1 / Q9UGP4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.31
Gene start: 45555394
Gene end: 45686338
  
Corresponding Affymetrix probe sets: 218850_s_at (Human Genome U133 Plus 2.0 Array)   222353_at (Human Genome U133 Plus 2.0 Array)   222762_x_at (Human Genome U133 Plus 2.0 Array)   234687_x_at (Human Genome U133 Plus 2.0 Array)   234743_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000273317
Ensembl peptide - ENSP00000394537
NCBI entrez gene - 8994     See in Manteia.
OMIM - 604543
RefSeq - NM_014240
RefSeq Peptide - NP_055055
swissprot - C9JRJ5
swissprot - Q9UGP4
Ensembl - ENSG00000144791
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01043952.1ENSDARG00000110954Danio rerio
 LIMD1ENSGALG00000035623Gallus gallus
 Limd1ENSMUSG00000025239Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WTIP / A6NIX2 / WT1 interacting proteinENSG0000014227931
AJUBA / Q96IF1 / ajuba LIM proteinENSG0000012947428
LPP / Q93052 / LIM domain containing preferred translocation partner in lipomaENSG0000014501224
ZYX / zyxin / Q15942ENSG0000015984023
TRIP6 / Q15654 / thyroid hormone receptor interactor 6ENSG0000008707720
FBLIM1 / Q8WUP2 / filamin binding LIM protein 1ENSG0000016245813
ABLIM1 / O14639 / actin binding LIM protein 1ENSG0000009920411
ABLIM2 / Q6H8Q1 / actin binding LIM protein family member 2ENSG0000016399510
ABLIM3 / O94929 / actin binding LIM protein family member 3ENSG0000017321010
DMTN / Q08495 / dematin actin binding proteinENSG000001588564


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type
 IPR028734  LIM domain-containing protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0016310 phosphorylation IDA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0033962 cytoplasmic mRNA processing body assembly IMP
 biological_processGO:0035195 gene silencing by miRNA IMP
 biological_processGO:0035331 negative regulation of hippo signaling IDA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IMP
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IBA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016442 RISC complex IDA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000131508 P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2  / reaction
 ENSG00000129521 EGLN3 / Q9H6Z9 / egl-9 family hypoxia inducible factor 3  / complex
 ENSG00000103363 ELOB / Q15370 / elongin B  / complex
 ENSG00000134086 VHL / P40337 / von Hippel-Lindau tumor suppressor  / complex
 ENSG00000154582 ELOC / Q15369 / elongin C  / complex
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / complex / reaction
 ENSG00000124440 HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit  / reaction / complex
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / complex / reaction
 ENSG00000109332 P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3  / reaction
 ENSG00000108094 CUL2 / Q13617 / cullin 2  / complex
 ENSG00000135766 EGLN1 / Q9GZT9 / egl-9 family hypoxia inducible factor 1  / complex
 ENSG00000072401 P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1  / reaction






 

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