ENSG00000129474


Homo sapiens

Features
Gene ID: ENSG00000129474
  
Biological name :AJUBA
  
Synonyms : AJUBA / ajuba LIM protein / Q96IF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q11.2
Gene start: 22971174
Gene end: 22982642
  
Corresponding Affymetrix probe sets: 1553764_a_at (Human Genome U133 Plus 2.0 Array)   225806_at (Human Genome U133 Plus 2.0 Array)   225807_at (Human Genome U133 Plus 2.0 Array)   243446_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452369
Ensembl peptide - ENSP00000354491
Ensembl peptide - ENSP00000262713
Ensembl peptide - ENSP00000451772
Ensembl peptide - ENSP00000452325
Ensembl peptide - ENSP00000380543
Ensembl peptide - ENSP00000451649
NCBI entrez gene - 84962     See in Manteia.
OMIM - 609066
RefSeq - NM_198086
RefSeq - NM_001289097
RefSeq - NM_032876
RefSeq Peptide - NP_001276026
RefSeq Peptide - NP_932352
RefSeq Peptide - NP_116265
swissprot - Q96IF1
swissprot - G3V481
swissprot - G3V5F5
swissprot - H0YJL9
Ensembl - ENSG00000129474
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ajubaENSDARG00000077842Danio rerio
 AjubaENSMUSG00000022178Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WTIP / A6NIX2 / WT1 interacting proteinENSG0000014227936
LIMD1 / Q9UGP4 / LIM domains containing 1ENSG0000014479135
LPP / Q93052 / LIM domain containing preferred translocation partner in lipomaENSG0000014501223
ZYX / zyxin / Q15942ENSG0000015984022
TRIP6 / Q15654 / thyroid hormone receptor interactor 6ENSG0000008707721
FBLIM1 / Q8WUP2 / filamin binding LIM protein 1ENSG0000016245814
ABLIM1 / O14639 / actin binding LIM protein 1ENSG0000009920414
ABLIM2 / Q6H8Q1 / actin binding LIM protein family member 2ENSG0000016399511
ABLIM3 / O94929 / actin binding LIM protein family member 3ENSG0000017321010
DMTN / Q08495 / dematin actin binding proteinENSG000001588564


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0007010 cytoskeleton organization IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031328 positive regulation of cellular biosynthetic process IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IDA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0033674 positive regulation of kinase activity IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035195 gene silencing by miRNA IMP
 biological_processGO:0035313 wound healing, spreading of epidermal cells IEA
 biological_processGO:0035331 negative regulation of hippo signaling IDA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0046474 glycerophospholipid biosynthetic process IEA
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:1900037 regulation of cellular response to hypoxia IDA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IMP
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction IBA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045294 alpha-catenin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Regulation of PLK1 Activity at G2/M Transition
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087586 AURKA / O14965 / aurora kinase A  / reaction / complex






 

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