ENSMUSG00000022178


Mus musculus

Features
Gene ID: ENSMUSG00000022178
  
Biological name :Ajuba
  
Synonyms : Ajuba / LIM domain-containing protein ajuba / Q91XC0
  
Possible biological names infered from orthology : ajuba LIM protein / Q96IF1
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 54567472
Gene end: 54577558
  
Corresponding Affymetrix probe sets: 10419790 (MoGene1.0st)   1421344_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056977
NCBI entrez gene - 16475     See in Manteia.
MGI - MGI:1341886
RefSeq - NM_010590
RefSeq Peptide - NP_034720
swissprot - Q91XC0
Ensembl - ENSMUSG00000022178
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ajubaENSDARG00000077842Danio rerio
 AJUBAENSG00000129474Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*ENSMUSG0000002523935
Wtip / Q7TQJ8 / WT1-interacting protein / A6NIX2*ENSMUSG0000003645934
Lpp / Q8BFW7 / Lipoma-preferred partner homolog / Q93052* / LIM domain containing preferred translocation partner in lipoma*ENSMUSG0000003330622
Zyx / zyxin / Q62523 / Q15942*ENSMUSG0000002986022
Trip6 / Q9Z1Y4 / thyroid hormone receptor interactor 6 / Q15654*ENSMUSG0000002334821
Fblim1 / Q71FD7 / Filamin-binding LIM protein 1 / Q8WUP2*ENSMUSG0000000621918
Ablim1 / Q8K4G5 / actin-binding LIM protein 1 / O14639*ENSMUSG0000002508514
Ablim2 / Q8BL65 / actin-binding LIM protein 2 / Q6H8Q1* / actin binding LIM protein family member 2*ENSMUSG0000002909511
Ablim3 / Q69ZX8 / actin binding LIM protein family, member 3 / O94929*ENSMUSG0000003273510
Dmtn / Q9WV69 / Dematin / Q08495* / dematin actin binding protein*ENSMUSG000000220993


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007010 cytoskeleton organization IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IMP
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031328 positive regulation of cellular biosynthetic process IMP
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0033673 negative regulation of kinase activity IDA
 biological_processGO:0033674 positive regulation of kinase activity IDA
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0035195 gene silencing by miRNA IEA
 biological_processGO:0035313 wound healing, spreading of epidermal cells IMP
 biological_processGO:0035329 hippo signaling IBA
 biological_processGO:0035331 negative regulation of hippo signaling IEA
 biological_processGO:0043087 regulation of GTPase activity IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0046474 glycerophospholipid biosynthetic process IMP
 biological_processGO:0048041 focal adhesion assembly IMP
 biological_processGO:1900037 regulation of cellular response to hypoxia IEA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IEA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045294 alpha-catenin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Regulation of PLK1 Activity at G2/M Transition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027496 Aurka / P97477 / Aurora kinase A / O14965*  / complex / reaction






 

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