ENSMUSG00000022099


Mus musculus

Features
Gene ID: ENSMUSG00000022099
  
Biological name :Dmtn
  
Synonyms : Dematin / Dmtn / Q9WV69
  
Possible biological names infered from orthology : dematin actin binding protein / Q08495
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 70601263
Gene end: 70636048
  
Corresponding Affymetrix probe sets: 10421418 (MoGene1.0st)   1438189_s_at (Mouse Genome 430 2.0 Array)   1445439_at (Mouse Genome 430 2.0 Array)   1460223_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022694
Ensembl peptide - ENSMUSP00000022695
Ensembl peptide - ENSMUSP00000106612
Ensembl peptide - ENSMUSP00000153828
Ensembl peptide - ENSMUSP00000153945
Ensembl peptide - ENSMUSP00000154045
Ensembl peptide - ENSMUSP00000154695
Ensembl peptide - ENSMUSP00000154775
Ensembl peptide - ENSMUSP00000154373
NCBI entrez gene - 13829     See in Manteia.
MGI - MGI:99670
RefSeq - XM_017315840
RefSeq - NM_001252662
RefSeq - NM_001252663
RefSeq - NM_001252664
RefSeq - NM_001252665
RefSeq - NM_001252666
RefSeq - NM_013514
RefSeq - XM_006518540
RefSeq - XM_006518541
RefSeq - XM_006518542
RefSeq - XM_011244949
RefSeq - XM_011244950
RefSeq - XM_017315838
RefSeq - XM_017315839
RefSeq - XM_006518522
RefSeq - XM_006518523
RefSeq - XM_006518525
RefSeq - XM_006518526
RefSeq - XM_006518527
RefSeq - XM_006518530
RefSeq - XM_006518531
RefSeq - XM_006518532
RefSeq - XM_006518533
RefSeq - XM_006518534
RefSeq - XM_006518535
RefSeq - XM_006518536
RefSeq - XM_006518537
RefSeq - XM_006518539
RefSeq Peptide - NP_001239595
RefSeq Peptide - NP_001239593
RefSeq Peptide - NP_001239594
RefSeq Peptide - NP_001239592
RefSeq Peptide - NP_038542
RefSeq Peptide - NP_001239591
swissprot - Q9WV69
Ensembl - ENSMUSG00000022099
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX465198.3ENSDARG00000116484Danio rerio
 dmtnENSDARG00000013110Danio rerio
 DMTNENSG00000158856Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ablim1 / Q8K4G5 / actin-binding LIM protein 1 / O14639*ENSMUSG0000002508546
Ablim3 / Q69ZX8 / actin binding LIM protein family, member 3 / O94929*ENSMUSG0000003273538
Ablim2 / Q8BL65 / actin-binding LIM protein 2 / Q6H8Q1* / actin binding LIM protein family member 2*ENSMUSG0000002909532
Wtip / Q7TQJ8 / WT1-interacting protein / A6NIX2*ENSMUSG000000364597
Limd1 / Q9QXD8 / LIM domain-containing protein 1 / Q9UGP4* / LIM domains containing 1*ENSMUSG000000252397
Trip6 / Q9Z1Y4 / thyroid hormone receptor interactor 6 / Q15654*ENSMUSG000000233486
Lpp / Q8BFW7 / Lipoma-preferred partner homolog / Q93052* / LIM domain containing preferred translocation partner in lipoma*ENSMUSG000000333066
Fblim1 / Q71FD7 / Filamin-binding LIM protein 1 / Q8WUP2*ENSMUSG000000062196
Zyx / zyxin / Q62523 / Q15942*ENSMUSG000000298605
Ajuba / Q91XC0 / LIM domain-containing protein ajuba / Q96IF1* / ajuba LIM protein*ENSMUSG000000221785


Protein motifs (from Interpro)
Interpro ID Name
 IPR003128  Villin headpiece
 IPR032402  Putative adherens-junction anchoring domain
 IPR036886  Villin headpiece domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0010591 regulation of lamellipodium assembly ISS
 biological_processGO:0010763 positive regulation of fibroblast migration IDA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030194 positive regulation of blood coagulation IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization ISS
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IMP
 biological_processGO:0035585 calcium-mediated signaling using extracellular calcium source IMP
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0051017 actin filament bundle assembly ISO
 biological_processGO:0051489 regulation of filopodium assembly ISO
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0051895 negative regulation of focal adhesion assembly IMP
 biological_processGO:0065003 protein-containing complex assembly IDA
 biological_processGO:0070560 protein secretion by platelet IMP
 biological_processGO:0071277 cellular response to calcium ion IMP
 biological_processGO:0071320 cellular response to cAMP ISS
 biological_processGO:0090303 positive regulation of wound healing IMP
 biological_processGO:0090315 negative regulation of protein targeting to membrane IMP
 biological_processGO:0090527 actin filament reorganization IMP
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1901731 positive regulation of platelet aggregation IMP
 biological_processGO:2001046 positive regulation of integrin-mediated signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0014731 spectrin-associated cytoskeleton ISS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0031095 platelet dense tubular network membrane ISO
 cellular_componentGO:0031253 cell projection membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0005102 signaling receptor binding ISS
 molecular_functionGO:0030507 spectrin binding ISO
 molecular_functionGO:0043621 protein self-association ISS


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030000 Add2 / Q9QYB8 / Beta-adducin / P35612* / adducin 2*  / reaction / complex
 ENSMUSG00000029106 Add1 / Q9QYC0 / Mus musculus adducin 1 (alpha) (Add1), transcript variant 5, mRNA. / P35611* / adducin 1*  / complex / reaction
 ENSMUSG00000025026 Add3 / Q9QYB5 / Gamma-adducin / Q9UEY8* / adducin 3*  / reaction / complex






 

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