ENSMUSG00000029106


Mus musculus

Features
Gene ID: ENSMUSG00000029106
  
Biological name :Add1
  
Synonyms : Add1 / Mus musculus adducin 1 (alpha) (Add1), transcript variant 5, mRNA. / Q9QYC0
  
Possible biological names infered from orthology : adducin 1 / P35611
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B2
Gene start: 34573664
Gene end: 34632308
  
Corresponding Affymetrix probe sets: 10521222 (MoGene1.0st)   1420953_at (Mouse Genome 430 2.0 Array)   1420954_a_at (Mouse Genome 430 2.0 Array)   1450054_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118539
Ensembl peptide - ENSMUSP00000116075
Ensembl peptide - ENSMUSP00000121402
Ensembl peptide - ENSMUSP00000144673
Ensembl peptide - ENSMUSP00000001108
Ensembl peptide - ENSMUSP00000052266
Ensembl peptide - ENSMUSP00000109974
Ensembl peptide - ENSMUSP00000109977
Ensembl peptide - ENSMUSP00000109979
Ensembl peptide - ENSMUSP00000114984
NCBI entrez gene - 11518     See in Manteia.
MGI - MGI:87918
RefSeq - XM_017320617
RefSeq - XM_006503672
RefSeq - XM_006503673
RefSeq - XM_006503674
RefSeq - XM_006503675
RefSeq - XM_006503676
RefSeq - XM_006503677
RefSeq - XM_006503678
RefSeq - XM_006503679
RefSeq - XM_006503680
RefSeq - XM_006503681
RefSeq - XM_017320613
RefSeq - XM_017320614
RefSeq - XM_017320615
RefSeq - XM_017320616
RefSeq - NM_001024458
RefSeq - NM_001102444
RefSeq - NM_001331081
RefSeq - NM_013457
RefSeq - XM_006503668
RefSeq - XM_006503669
RefSeq - XM_006503670
RefSeq - XM_006503671
RefSeq Peptide - NP_001318010
RefSeq Peptide - NP_001318016
RefSeq Peptide - NP_038485
RefSeq Peptide - NP_001019629
RefSeq Peptide - NP_001095914
RefSeq Peptide - NP_001318009
swissprot - A0A0J9YVI4
swissprot - E9Q1K3
swissprot - Q9QYC0
swissprot - F6RDR0
swissprot - F6V4G5
swissprot - F8WGR0
swissprot - F8WHZ9
swissprot - D3Z0T1
Ensembl - ENSMUSG00000029106
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 add1ENSDARG00000103962Danio rerio
 ADD1ENSGALG00000015664Gallus gallus
 ADD1ENSG00000087274Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Add3 / Q9QYB5 / Gamma-adducin / Q9UEY8* / adducin 3*ENSMUSG0000002502649
Add2 / Q9QYB8 / Beta-adducin / P35612* / adducin 2*ENSMUSG0000003000046


Protein motifs (from Interpro)
Interpro ID Name
 IPR001303  Class II aldolase/adducin N-terminal
 IPR027766  Alpha-adducin
 IPR036409  Class II aldolase/adducin N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006884 cell volume homeostasis IMP
 biological_processGO:0020027 hemoglobin metabolic process IMP
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:1903142 positive regulation of establishment of endothelial barrier IMP
 biological_processGO:1903393 positive regulation of adherens junction organization IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0008290 F-actin capping protein complex IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity IDA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0030507 spectrin binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0001893 non-obstructive hydrocephaly "abnormal cerebrospinal fluid absorption where there is no obstruction to fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0008850 increased hemoglobin concentration distribution width "higher than normal standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations; high HDW is indicative of some types of anemia/thalassemia" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030000 Add2 / Q9QYB8 / Beta-adducin / P35612* / adducin 2*  / complex
 ENSMUSG00000025026 Add3 / Q9QYB5 / Gamma-adducin / Q9UEY8* / adducin 3*  / complex
 ENSMUSG00000022099 Dmtn / Q9WV69 / Dematin / Q08495* / dematin actin binding protein*  / complex / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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