ENSMUSG00000030000


Mus musculus

Features
Gene ID: ENSMUSG00000030000
  
Biological name :Add2
  
Synonyms : Add2 / Beta-adducin / Q9QYB8
  
Possible biological names infered from orthology : adducin 2 / P35612
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 86028681
Gene end: 86124409
  
Corresponding Affymetrix probe sets: 10539669 (MoGene1.0st)   1421975_a_at (Mouse Genome 430 2.0 Array)   1431076_at (Mouse Genome 430 2.0 Array)   1435287_at (Mouse Genome 430 2.0 Array)   1450442_at (Mouse Genome 430 2.0 Array)   1451914_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145494
Ensembl peptide - ENSMUSP00000145296
Ensembl peptide - ENSMUSP00000145452
Ensembl peptide - ENSMUSP00000032069
Ensembl peptide - ENSMUSP00000144694
Ensembl peptide - ENSMUSP00000144849
Ensembl peptide - ENSMUSP00000145034
Ensembl peptide - ENSMUSP00000145104
Ensembl peptide - ENSMUSP00000145160
NCBI entrez gene - 11519     See in Manteia.
MGI - MGI:87919
RefSeq - NM_001271857
RefSeq - NM_001271858
RefSeq - NM_001271859
RefSeq - NM_001271860
RefSeq - NM_001271861
RefSeq - NM_013458
RefSeq Peptide - NP_038486
RefSeq Peptide - NP_001258786
RefSeq Peptide - NP_001258787
RefSeq Peptide - NP_001258789
RefSeq Peptide - NP_001258790
RefSeq Peptide - NP_001258788
swissprot - A0A0N4SWF0
swissprot - Q9QYB8
Ensembl - ENSMUSG00000030000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 add2ENSDARG00000074581Danio rerio
 ADD2ENSGALG00000026948Gallus gallus
 ADD2ENSG00000075340Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Add3 / Q9QYB5 / Gamma-adducin / Q9UEY8* / adducin 3*ENSMUSG0000002502652
Add1 / Q9QYC0 / Mus musculus adducin 1 (alpha) (Add1), transcript variant 5, mRNA. / P35611* / adducin 1*ENSMUSG0000002910647


Protein motifs (from Interpro)
Interpro ID Name
 IPR001303  Class II aldolase/adducin N-terminal
 IPR027773  Beta-adducin
 IPR036409  Class II aldolase/adducin N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0032092 positive regulation of protein binding ISO
 biological_processGO:0050900 leukocyte migration ISO
 biological_processGO:0050901 leukocyte tethering or rolling ISO
 biological_processGO:0051016 barbed-end actin filament capping ISO
 biological_processGO:0051017 actin filament bundle assembly ISO
 biological_processGO:0065003 protein-containing complex assembly ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008290 F-actin capping protein complex ISO
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0044853 plasma membrane raft ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity IDA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030507 spectrin binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0051015 actin filament binding ISO


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0002923 increased post-tetanic potential "increase in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0006265 increased pulse pressure "increase in the difference between systolic and diastolic blood pressure" [RGD:Rat Genome Database submission]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029106 Add1 / Q9QYC0 / Mus musculus adducin 1 (alpha) (Add1), transcript variant 5, mRNA. / P35611* / adducin 1*  / complex
 ENSMUSG00000022099 Dmtn / Q9WV69 / Dematin / Q08495* / dematin actin binding protein*  / reaction / complex






 

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