ENSMUSG00000025026


Mus musculus

Features
Gene ID: ENSMUSG00000025026
  
Biological name :Add3
  
Synonyms : Add3 / Gamma-adducin / Q9QYB5
  
Possible biological names infered from orthology : adducin 3 / Q9UEY8
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 53140445
Gene end: 53247399
  
Corresponding Affymetrix probe sets: 10463911 (MoGene1.0st)   1423297_at (Mouse Genome 430 2.0 Array)   1423298_at (Mouse Genome 430 2.0 Array)   1426574_a_at (Mouse Genome 430 2.0 Array)   1456162_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025999
Ensembl peptide - ENSMUSP00000052245
Ensembl peptide - ENSMUSP00000107370
NCBI entrez gene - 27360     See in Manteia.
MGI - MGI:1351615
RefSeq - NM_001277100
RefSeq - NM_001164099
RefSeq - NM_001164100
RefSeq - NM_001164101
RefSeq - NM_013758
RefSeq Peptide - NP_001157571
RefSeq Peptide - NP_001157572
RefSeq Peptide - NP_001157573
RefSeq Peptide - NP_001264029
RefSeq Peptide - NP_038786
swissprot - Q3UNK1
swissprot - Q9QYB5
Ensembl - ENSMUSG00000025026
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 add3aENSDARG00000040874Danio rerio
 ADD3ENSGALG00000008542Gallus gallus
 ADD3ENSG00000148700Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Add2 / Q9QYB8 / Beta-adducin / P35612* / adducin 2*ENSMUSG0000003000054
Add1 / Q9QYC0 / Mus musculus adducin 1 (alpha) (Add1), transcript variant 5, mRNA. / P35611* / adducin 1*ENSMUSG0000002910651


Protein motifs (from Interpro)
Interpro ID Name
 IPR001303  Class II aldolase/adducin N-terminal
 IPR027772  Gamma-adducin
 IPR036409  Class II aldolase/adducin N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity IDA
 molecular_functionGO:0005516 calmodulin binding IEA


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fastheo/Fastheo
Genetic Background: either: (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd) or (involves: C57BL/6JAnu * C57BL/10SnSg * C57BR/cd * CBA/CaJAnu)

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029106 Add1 / Q9QYC0 / Mus musculus adducin 1 (alpha) (Add1), transcript variant 5, mRNA. / P35611* / adducin 1*  / complex
 ENSMUSG00000022099 Dmtn / Q9WV69 / Dematin / Q08495* / dematin actin binding protein*  / complex / reaction






 

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