ENSG00000087274


Homo sapiens

Features
Gene ID: ENSG00000087274
  
Biological name :ADD1
  
Synonyms : ADD1 / adducin 1 / P35611
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p16.3
Gene start: 2843857
Gene end: 2930076
  
Corresponding Affymetrix probe sets: 208030_s_at (Human Genome U133 Plus 2.0 Array)   214726_x_at (Human Genome U133 Plus 2.0 Array)   214736_s_at (Human Genome U133 Plus 2.0 Array)   238939_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421918
Ensembl peptide - ENSP00000421907
Ensembl peptide - ENSP00000423024
Ensembl peptide - ENSP00000441388
Ensembl peptide - ENSP00000438069
Ensembl peptide - ENSP00000426700
Ensembl peptide - ENSP00000425703
Ensembl peptide - ENSP00000424143
Ensembl peptide - ENSP00000264758
Ensembl peptide - ENSP00000348100
Ensembl peptide - ENSP00000381191
Ensembl peptide - ENSP00000381193
Ensembl peptide - ENSP00000381197
Ensembl peptide - ENSP00000399828
NCBI entrez gene - 118     See in Manteia.
OMIM - 102680
RefSeq - XM_017007710
RefSeq - NM_001286645
RefSeq - NM_001354754
RefSeq - NM_001354755
RefSeq - NM_014189
RefSeq - NM_014190
RefSeq - NM_176801
RefSeq - XM_005247933
RefSeq - XM_005247934
RefSeq - XM_005247935
RefSeq - XM_005247936
RefSeq - XM_005247937
RefSeq - XM_017007703
RefSeq - XM_017007704
RefSeq - XM_017007705
RefSeq - XM_017007706
RefSeq - XM_017007707
RefSeq - XM_017007708
RefSeq - XM_017007709
RefSeq - NM_001119
RefSeq Peptide - NP_001341683
RefSeq Peptide - NP_001341684
RefSeq Peptide - NP_001341688
RefSeq Peptide - NP_054908
RefSeq Peptide - NP_054909
RefSeq Peptide - NP_789771
RefSeq Peptide - NP_001110
RefSeq Peptide - NP_001273574
swissprot - A0A0A0MSR2
swissprot - E7EV99
swissprot - P35611
swissprot - E7ENY0
swissprot - D6RJE2
swissprot - D6RF25
swissprot - D6RAH3
swissprot - H0Y9H2
swissprot - H0YFD8
swissprot - H0YG19
Ensembl - ENSG00000087274
  
Related genetic diseases (OMIM): 145500 - {Hypertension, essential, salt-sensitive}, 145500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 add1ENSDARG00000103962Danio rerio
 ADD1ENSGALG00000015664Gallus gallus
 Add1ENSMUSG00000029106Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADD3 / Q9UEY8 / adducin 3ENSG0000014870047
ADD2 / P35612 / adducin 2ENSG0000007534044


Protein motifs (from Interpro)
Interpro ID Name
 IPR001303  Class II aldolase/adducin N-terminal
 IPR027766  Alpha-adducin
 IPR036409  Class II aldolase/adducin N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006884 cell volume homeostasis IEA
 biological_processGO:0020027 hemoglobin metabolic process IEA
 biological_processGO:0030036 actin cytoskeleton organization IC
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0051016 barbed-end actin filament capping IDA
 biological_processGO:0051017 actin filament bundle assembly IDA
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:1903142 positive regulation of establishment of endothelial barrier IDA
 biological_processGO:1903393 positive regulation of adherens junction organization IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0008290 F-actin capping protein complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0030507 spectrin binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins
XBP1(S) activates chaperone genes
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000075340 ADD2 / P35612 / adducin 2  / complex
 ENSG00000158856 DMTN / Q08495 / dematin actin binding protein  / complex / reaction
 ENSG00000148700 ADD3 / Q9UEY8 / adducin 3  / complex
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction






 

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