ENSG00000164305


Homo sapiens

Features
Gene ID: ENSG00000164305
  
Biological name :CASP3
  
Synonyms : CASP3 / caspase 3 / P42574
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q35.1
Gene start: 184627696
Gene end: 184649509
  
Corresponding Affymetrix probe sets: 202763_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407142
Ensembl peptide - ENSP00000377213
Ensembl peptide - ENSP00000428372
Ensembl peptide - ENSP00000428929
Ensembl peptide - ENSP00000311032
Ensembl peptide - ENSP00000377210
NCBI entrez gene - 836     See in Manteia.
OMIM - 600636
RefSeq - XM_011532301
RefSeq - NM_001354777
RefSeq - NM_001354778
RefSeq - NM_001354779
RefSeq - NM_001354780
RefSeq - NM_001354783
RefSeq - NM_004346
RefSeq - NM_032991
RefSeq Peptide - NP_004337
RefSeq Peptide - NP_116786
RefSeq Peptide - NP_001341707
RefSeq Peptide - NP_001341708
RefSeq Peptide - NP_001341709
RefSeq Peptide - NP_001341706
RefSeq Peptide - NP_001341710
RefSeq Peptide - NP_001341711
RefSeq Peptide - NP_001341712
swissprot - P42574
swissprot - C9JXR7
swissprot - A8MVM1
Ensembl - ENSG00000164305
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp3aENSDARG00000017905Danio rerio
 casp3bENSDARG00000055045Danio rerio
 CASP3ENSGALG00000010638Gallus gallus
 Casp3ENSMUSG00000031628Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP7 / P55210 / caspase 7ENSG0000016580651
CASP6 / P55212 / caspase 6ENSG0000013879439
CASP8 / Q14790 / caspase 8ENSG0000006401236
CASP9 / P55211 / caspase 9ENSG0000013290634
CASP10 / Q92851 / caspase 10ENSG0000000340031
CASP14 / P31944 / caspase 14ENSG0000010514128
CASP2 / P42575 / caspase 2ENSG0000010614427


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0006309 apoptotic DNA fragmentation TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress IEA
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c TAS
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010038 response to metal ion IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030216 keratinocyte differentiation IBA
 biological_processGO:0030218 erythrocyte differentiation TAS
 biological_processGO:0030220 platelet formation TAS
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0032025 response to cobalt ion IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034349 glial cell apoptotic process IEA
 biological_processGO:0034612 response to tumor necrosis factor TAS
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035329 hippo signaling TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IDA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0072734 cellular response to staurosporine IMP
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand TAS
 biological_processGO:0097194 execution phase of apoptosis IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0031264 death-inducing signaling complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity EXP
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0005123 death receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process TAS
 molecular_functionGO:0016005 phospholipase A2 activator activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IMP
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP


Pathways (from Reactome)
Pathway description
Activation of caspases through apoptosome-mediated cleavage
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
Degradation of the extracellular matrix
Signaling by Hippo
NADE modulates death signalling
Activation of DNA fragmentation factor
Stimulation of the cell death response by PAK-2p34
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
via Dependence Receptors in the absence of ligand
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184047 DIABLO / Q9NR28 / diablo IAP-binding mitochondrial protein  / complex / reaction
 ENSG00000102572 STK24 / Q9Y6E0 / serine/threonine kinase 24  / reaction
 ENSG00000104375 STK3 / Q13188 / serine/threonine kinase 3  / reaction
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / reaction
 ENSG00000134982 APC / P25054 / APC, WNT signaling pathway regulator  / reaction
 ENSG00000119139 TJP2 / Q9UDY2 / tight junction protein 2  / reaction
 ENSG00000046604 DSG2 / Q14126 / desmoglein 2  / reaction
 ENSG00000096696 DSP / P15924 / desmoplakin  / reaction
 ENSG00000136279 DBNL / Q9UJU6 / drebrin like  / reaction
 ENSG00000100813 ACIN1 / Q9UKV3 / apoptotic chromatin condensation inducer 1  / reaction
 ENSG00000197694 Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1  / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction
 ENSG00000026025 VIM / P08670 / vimentin  / reaction
 ENSG00000081277 PKP1 / Q13835 / plakophilin 1  / reaction
 ENSG00000087274 ADD1 / P35611 / adducin 1  / reaction
 ENSG00000169598 DFFB / O76075 / DNA fragmentation factor subunit beta  / reaction
 ENSG00000113763 UNC5A / Q6ZN44 / unc-5 netrin receptor A  / reaction
 ENSG00000134760 DSG1 / Q02413 / desmoglein 1  / reaction
 ENSG00000039068 CDH1 / P12830 / cadherin 1  / reaction
 ENSG00000148180 GSN / P06396 / gelsolin  / reaction
 ENSG00000101966 XIAP / P98170 / X-linked inhibitor of apoptosis  / complex
 ENSG00000148935 GAS2 / O43903 / growth arrest specific 2  / reaction
 ENSG00000102010 BMX / P51813 / BMX non-receptor tyrosine kinase  / reaction
 ENSG00000197822 OCLN / Q16625 / occludin  / reaction
 ENSG00000134602 STK26 / Q9P289 / serine/threonine kinase 26  / reaction
 ENSG00000104067 TJP1 / Q07157 / tight junction protein 1  / reaction
 ENSG00000163932 PRKCD / Q05655 / protein kinase C delta  / reaction
 ENSG00000160049 DFFA / O00273 / DNA fragmentation factor subunit alpha  / reaction
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction
 ENSG00000134757 DSG3 / P32926 / desmoglein 3  / reaction
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / reaction
 ENSG00000186868 MAPT / P10636 / microtubule associated protein tau  / reaction
 ENSG00000164305 CASP3 / P42574 / caspase 3  / complex
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / reaction
 ENSG00000172349 IL16 / Q14005 / interleukin 16  / reaction
 ENSG00000168522 FNTA / P49354 / farnesyltransferase, CAAX box, alpha  / reaction
 ENSG00000101109 STK4 / Q13043 / serine/threonine kinase 4  / reaction
 ENSG00000107731 UNC5B / Q8IZJ1 / unc-5 netrin receptor B  / reaction
 ENSG00000151748 SAV1 / Q9H4B6 / salvador family WW domain containing protein 1  / reaction
 ENSG00000132906 CASP9 / P55211 / caspase 9  / reaction
 ENSG00000166681 BEX3 / Q00994 / brain expressed X-linked 3  / reaction






 

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