ENSG00000134757


Homo sapiens

Features
Gene ID: ENSG00000134757
  
Biological name :DSG3
  
Synonyms : desmoglein 3 / DSG3 / P32926
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q12.1
Gene start: 31447795
Gene end: 31478702
  
Corresponding Affymetrix probe sets: 205595_at (Human Genome U133 Plus 2.0 Array)   235075_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000257189
NCBI entrez gene - 1830     See in Manteia.
OMIM - 169615
RefSeq - NM_001944
RefSeq - XM_011525850
RefSeq Peptide - NP_001935
swissprot - P32926
Ensembl - ENSG00000134757
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-74h11.1ENSDARG00000062750Danio rerio
 ENSGALG00000017398Gallus gallus
 Dsg3ENSMUSG00000056632Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DSG4 / Q86SJ6 / desmoglein 4ENSG0000017506549
DSG1 / Q02413 / desmoglein 1ENSG0000013476042
DSG2 / Q14126 / desmoglein 2ENSG0000004660438


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR009122  Desmosomal cadherin
 IPR009123  Desmoglein
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0031424 keratinization TAS
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0001533 cornified envelope TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cell adhesion proteins
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction






 

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