| MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0000324 | increased mast cell number | "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dsg3bal/Dsg3bal
Genetic Background: C57BL/6J-Dsg3bal/J
|
| MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
Allelic Composition: Dsg3bal/Dsg3bal
Genetic Background: C57BL/6J-Dsg3bal/J
|
| MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
Allelic Composition: Dsg3bal/Dsg3bal
Genetic Background: C57BL/6J-Dsg3bal/J
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0000416 | sparse fur | "fur that is significantly less dense" [J:46854] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
Allelic Composition: Dsg3bal/Dsg3bal
Genetic Background: C57BL/6J-Dsg3bal/J
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0000418 | patchy hair | "uneven spots of hair growth on the body" [J:26975] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0000427 | abnormal hair cycle | "aberrant growth or asynchronous timing of the hair growth " [J:65302] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0000762 | abnormal tongue morphology | "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0001208 | blistering | "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
Allelic Composition: Dsg3bal/Dsg3bal
Genetic Background: C57BL/6J-Dsg3bal/J
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001219 | thickened epidermis | "increase in the width of the epidermal cell layer in the skin" [J:65146] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0001234 | absent suprabasal layer | "missing suprobasal layer of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0001236 | abnormal spinous layer morphology | "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0001852 | conjunctivitis | "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0002073 | abnormal hair growth | "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0002132 | abnormal respiratory system morphology | "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0002249 | abnormal larynx morphology | "any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0002256 | abnormal laryngeal cartilage morphology | "any structural anomaly of the cartilagenous structures that support the larynx" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0002285 | abnormal tracheal ciliated epithelium morphology | "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0002406 | increased susceptibility to infection | "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0002497 | increased IgE | "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dsg3bal/Dsg3bal
Genetic Background: C57BL/6J-Dsg3bal/J
|
| MP:0003453 | abnormal keratinocyte physiology | "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0003566 | abnormal cell adhesion | "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0003747 | mouth mucosal ulceration | "lesions through the mucous membrane of the mouth" [ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0003809 | abnormal hair shaft morphology | "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0004241 | acantholysis | "separation of prickle cells of the spinous layer of the epidermis, resulting in atrophy of the prickle cell layer, as in conditions such as pemphigus vulgaris and Darier disease" [MESH:C17.800.865.070] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0005114 | premature hair loss | "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
|
| MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0005668 | decreased circulating leptin level | "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0008083 | decreased single-positive T cell number | "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0008190 | decreased transitional stage B cell number | "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0008209 | decreased pre-B cell number | "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0008215 | decreased immature B cell number | "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0008844 | decreased subcutaneous adipose tissue amount | "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0009247 | meteorism | "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0009474 | thick epidermal spinous layer | "increased thickness of the stratum spinosum; the polyhedral cell layer" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0009598 | thin epidermis stratum granulosum | "decreased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
|
| MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0010099 | abnormal thoracic cage shape | "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0010371 | abnormal epiglottis morphology | "any structural anomaly of the most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0011084 | partial lethality at weaning | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith] |
Show
Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0013752 | stridor | "a high-pitched breath sound resulting from turbulent air flow in the larynx or lower in the bronchial tree; it should not to be confused with stertor which is a noise originating in the pharynx; stridor is a physical sign which is caused by a narrowed or obstructed airway; it can be inspiratory, expiratory or biphasic, although it is usually heard during inspiration" [http://en.wikipedia.org/wiki/Stridor, MGI:Anna] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0030000 | abnormal subglottis morphology | "any structural anomaly of the lower portion of the larynx, extending from just beneath the vocal cords down to the top of the trachea; the structures in the subglottis are implicated in the regulation of the temperature of the breath" [https://en.wikipedia.org/wiki/Subglottis, ORCID:orcid.org/0000-0002-6490-7723] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0030001 | subglottis stenosis | "congenital or acquired narrowing of the subglottic airway, extending from just beneath the vocal cords down to the top of the trachea; subglottic stenosis can present as a life-threatening airway emergency and may require tracheotomy" [https://en.wikipedia.org/wiki/Subglottis, ORCID:orcid.org/0000-0002-6490-7723, PMID:23770197, PMID:25542773] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
| MP:0030520 | oral mucosa blisters | "localized pockets of fluid that form within or beneath the oral mucosa; may appear as pustules, vesicles, or bullae; color varies according to content of blister, which may include blood, serum, mucin, or suppuration" [https://books.google.com/books?isbn=0470673966, https://medical-dictionary.thefreedictionary.com/blisterform+oral+lesions] |
Show
Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSnJ
|
| MP:0030533 | abnormal snout skin morphology | "any anomaly in a zone of skin that is part of the snout" [UBERON:1000015] |
Show
Allelic Composition: Dsg3sqk/Dsg3sqk
Genetic Background: C57BL/6-Dsg3sqk
|
