ENSMUSG00000061928


Mus musculus

Features
Gene ID: ENSMUSG00000061928
  
Biological name :Dsg1b
  
Synonyms : Desmoglein-1-beta / Dsg1b / Q7TSF1
  
Possible biological names infered from orthology : desmoglein 1 / DSG1 / Q02413
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A2
Gene start: 20376729
Gene end: 20410196
  
Corresponding Affymetrix probe sets: 10454113 (MoGene1.0st)   10454129 (MoGene1.0st)   1455519_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076026
NCBI entrez gene - 225256     See in Manteia.
MGI - MGI:2664357
RefSeq - NM_181682
RefSeq Peptide - NP_859010
swissprot - B2RQH0
swissprot - Q7TSF1
Ensembl - ENSMUSG00000061928
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-74h11.1ENSDARG00000062750Danio rerio
 ENSGALG00000017398Gallus gallus
 DSG1ENSG00000134760Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dsg1a / Q61495 / Desmoglein-1-alpha / DSG1* / Q02413* / desmoglein 1*ENSMUSG0000006944195
Dsg1c / Q7TSF0 / Desmoglein-1-gamma / DSG1* / Q02413* / desmoglein 1*ENSMUSG0000003477479
Dsg4 / Q7TMD7 / Desmoglein-4 / Q86SJ6*ENSMUSG0000000180444
Dsg3 / desmoglein 3 / P32926*ENSMUSG0000005663238
Dsg2 / O55111 / Desmoglein-2 / Q14126*ENSMUSG0000004439334


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR009122  Desmosomal cadherin
 IPR009123  Desmoglein
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome IDA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0045295 gamma-catenin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cell adhesion proteins
Neutrophil degranulation
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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